{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:18:26Z","timestamp":1773706706776,"version":"3.50.1"},"reference-count":108,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Enzootic pneumonia (EP) caused by\n                    <jats:italic>Mycoplasma hyopneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>M. hyopneumoniae<\/jats:italic>\n                    ) has a significant impact on swine production. Subtherapeutic exposures of tylvalosin in swine, often due to inconsistent dosing in feed or water, promote antimicrobial resistance. This study investigated the efficacy of 1.0625\u2009mg\/kg\/day of tylvalosin administered for 7 days via feed to pigs experimentally infected with the UFV01 strain of\n                    <jats:italic>M. hyopneumoniae<\/jats:italic>\n                    and its impact on the respiratory microbiome. Thirty landrace x large white female piglets were divided into three groups: G1 (negative control,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), G2 (infected,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914) and G3 (infected and treated,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914). Clinical signs, seroconversion, macroscopic and microscopic lung lesions and bacterial load were assessed. The respiratory microbiota of swine was analysed through 16S rRNA gene sequencing, followed by bioinformatics analyses. While G1 piglets remained healthy, G2 and G3 piglets developed lung lesions consistent with EP, although no significant difference was observed between these groups. Seroconversion was higher in G2 (90.9%) than in G3 (45.5%) at 35 days post\u2010infection, suggesting modulation of the humoral immune response by tylvalosin. Microbiota analyses revealed a significant shift in post\u2010infection composition, with infected pigs exhibiting reduced alpha diversity and distinct beta diversity compared to healthy pigs.\n                    <jats:italic>M. hyopneumoniae<\/jats:italic>\n                    dominated the respiratory microbiome of infected animals, drastically reducing the abundance of other taxa, notably\n                    <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>\n                    . While tylvalosin treatment partially restored alpha diversity and shifted the microbiota composition towards the control group, it failed to eliminate\n                    <jats:italic>M. hyopneumoniae<\/jats:italic>\n                    .\n                    <jats:italic>Variivorax<\/jats:italic>\n                    ,\n                    <jats:italic>Ralstonia<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    were identified as potential biomarkers for respiratory health and treatment response. These findings emphasise the complex relationship between\n                    <jats:italic>M. hyopneumoniae<\/jats:italic>\n                    infection, suboptimal tylvalosin dosage and resulting respiratory microbiome dysbiosis. Identifying and correcting the inappropriate use of antimicrobial dosages in clinical and preventive treatments, as well as promoting research focused on optimising dosage strategies and management practices, is essential for swine production and for reducing antimicrobial resistance. Moreover, maintaining a balanced microbiota may be a key factor in achieving healthier swine production, both in terms of animal welfare and food safety for consumers.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/8903237","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T04:20:41Z","timestamp":1755577241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Use of Subtherapeutic Tylvalosin Against\n                    <i>Mycoplasma hyopneumoniae<\/i>\n                    : Implications For Respiratory Microbiome Dysbiosis and Swine Lung Health"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8169-9074","authenticated-orcid":false,"given":"Leonardo Te\u00f3filo","family":"Toledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-9720","authenticated-orcid":false,"given":"Richard Costa","family":"Polveiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Augustus","family":"Diamantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Manoel Rigueira","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-5076","authenticated-orcid":false,"given":"Carlos Eduardo Real","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9483-0800","authenticated-orcid":false,"given":"Eduardo de Freitas","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-2502","authenticated-orcid":false,"given":"Maria Aparecida Scatamburlo","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-5731","authenticated-orcid":false,"given":"Fernanda Simone","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_14_1_2","first-page":"779","article-title":"Mycoplasmosis","volume":"10","author":"Thacker E. L.","year":"2012","journal-title":"Diseases of Swine"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2020.105091"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11120668"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1994.204.01.102"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/10406387211069552"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.11.002"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.09.008"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12677"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2008.09.061"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-022-01038-9"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818030-3.00004-0"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani14040593"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto960401.x"},{"key":"e_1_2_14_14_2","first-page":"26","article-title":"Intra-Cellular Accumulation and Trans-Epithelial Transport of Aivlosin, Tylosin and Tilmicosin","volume":"60","author":"Stuart A. D.","year":"2007","journal-title":"The Pig Journal"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40813-020-00177-9"},{"key":"e_1_2_14_16_2","volume-title":"An Overview of Aivlosin and Why It Is Authorized in the EU","author":"European Medicines Agency","year":"2020"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1242146"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.04.015"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.4172\/jaa.1000031"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10010012"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-023-03571-x"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.165.12.342"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002625"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444302639.ch7"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444302639"},{"key":"e_1_2_14_26_2","first-page":"1129","article-title":"Agricultural Use of Antibiotics and the Evolution and Transfer of Antibiotic-Resistant Bacteria","volume":"159","author":"Khachatourians G. G.","year":"1998","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_14_27_2","volume-title":"Antimicrobial Resistance in Bacteria of Animal Origin","author":"Lees P.","year":"2006"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731119001903"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555819804.ch30"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.12730"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.02.018"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503141112"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1280588"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.09.022"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2010.09.001"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13770"},{"key":"e_1_2_14_37_2","article-title":"Tabelas Brasileiras Para Aves e Su\u00ednos","volume":"2","author":"Rostagno H. S.","year":"2011","journal-title":"Composi\u00e7\u00e3o De Alimentos e Necessidades Nutricionais v"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40813-022-00249-y"},{"key":"e_1_2_14_39_2","volume-title":"Veterinary Drug Handbook","author":"Plumb D. C.","year":"2011"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063879600800103"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108647"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1637-x"},{"key":"e_1_2_14_43_2","volume-title":"Descri\u00e7\u00e3o De Um Modelo Para Avalia\u00e7\u00e3o e Quantifica\u00e7\u00e3o De Les\u00f5es Pulmonares De Su\u00ednos e Formula\u00e7\u00e3o De Um \u00edndice Para Classifica\u00e7\u00e3o De Rebanhos","author":"Piffer I. A.","year":"1991"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.01.012"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007401"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.8"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.119"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm864"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00062-07"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_2_14_54_2","article-title":"MicrobiomeUtilities: Microbiomeutilities: Utilities for Microbiome Analytics. R Package Version 1.00. 17","volume":"1","author":"Shetty S.","year":"2022","journal-title":"Bioconductor"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_14_56_2","first-page":"265","article-title":"Non-Parametric Estimation of the Number of Classes; 1984. in a Population","volume":"11","author":"Chao A.","journal-title":"Scandinavian Journal of Statistics"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2003.tb01040.x"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538-7305.1948.tb00917.x"},{"key":"e_1_2_14_59_2","article-title":"Vegan: community ecology package","volume":"2","author":"Oksanen J.","year":"2019","journal-title":"R package version"},{"key":"e_1_2_14_60_2","unstructured":"LahtiL.andShettyS. Introduction to the Microbiome R Package; 2018."},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-15"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.21105\/joss.03201"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.11.4096-4101.2000"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.260-265.2001"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638718800170"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2009.04526.x"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.04167-13"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxad263"},{"key":"e_1_2_14_69_2","volume-title":"Generalized, Linear, and Mixed Models","author":"McCulloch C. E.","year":"2008"},{"key":"e_1_2_14_70_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780141105"},{"key":"e_1_2_14_74_2","article-title":"Ordinal\u2014Regression Models for Ordinal Data","volume":"10","author":"Christensen R. H. B.","year":"2019","journal-title":"R package version"},{"key":"e_1_2_14_75_2","first-page":"12","article-title":"Ordinal\u2014Regression Models for Ordinal Data","author":"Christensen R. H. B.","year":"2023","journal-title":"R package version"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-023-03735-9"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076591"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40813-024-00381-x"},{"key":"e_1_2_14_79_2","volume-title":"Essentials of Veterinary Hematology","author":"Jain N. C.","year":"1993"},{"key":"e_1_2_14_80_2","first-page":"221","article-title":"Intervalos De Refer\u00eancia Hematol\u00f3gicos e Bioqu\u00edmicos Para Su\u00ednos Mesti\u00e7os Noruegueses Em Crescimento","volume":"39","author":"Klem T. B.","year":"2010","journal-title":"Patologia Cl\u00ednica Veterin\u00e1ria"},{"key":"e_1_2_14_81_2","volume-title":"Bioqu\u00edmica Cl\u00ednica De Animais Dom\u00e9sticos (6a ed.)","author":"Kaneko J. J.","year":"2008"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2022.105877"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2020.1842659"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-022-01109-x"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2003.08.008"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.12.008"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175034"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1991.52.09.1497"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani13091493"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2024.110039"},{"key":"e_1_2_14_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126268"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.539"},{"key":"e_1_2_14_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9120674"},{"key":"e_1_2_14_94_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181503"},{"key":"e_1_2_14_95_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-303"},{"key":"e_1_2_14_96_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42523-020-00070-4"},{"key":"e_1_2_14_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/2042-5783-2-3"},{"key":"e_1_2_14_98_2","doi-asserted-by":"publisher","DOI":"10.1586\/ers.13.24"},{"key":"e_1_2_14_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12070866"},{"key":"e_1_2_14_100_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2020.1806664"},{"key":"e_1_2_14_101_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani13162611"},{"key":"e_1_2_14_102_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42523-024-00307-6"},{"key":"e_1_2_14_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-024-03424-z"},{"key":"e_1_2_14_104_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01771-7"},{"key":"e_1_2_14_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.572912"},{"key":"e_1_2_14_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.244"},{"key":"e_1_2_14_107_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00111.x"},{"key":"e_1_2_14_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24621"}],"container-title":["Transboundary and Emerging Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbed\/8903237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tbed\/8903237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbed\/8903237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:56:32Z","timestamp":1773003392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tbed\/8903237"}},"subtitle":[],"editor":[{"given":"Orhan","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/tbed\/8903237"],"URL":"https:\/\/doi.org\/10.1155\/tbed\/8903237","archive":["Portico"],"relation":{},"ISSN":["1865-1674","1865-1682"],"issn-type":[{"value":"1865-1674","type":"print"},{"value":"1865-1682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8903237"}}