{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:50:53Z","timestamp":1791291053448,"version":"4.3.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFD1800102"],"award-info":[{"award-number":["2025YFD1800102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transboundary and Emerging Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Brucellosis is an important zoonosis affecting public health and livestock production in Southeast Asia, but its regional epidemiology remains incompletely characterized. In this study, PubMed, Embase, Web of Science, and Scopus were searched for primary studies from the 11 Southeast Asian countries that reported serological findings, molecular detection, bacterial isolation, or\n                    <jats:italic>Brucella<\/jats:italic>\n                    species identification in human or animal populations. Publicly available PubMLST records were also analyzed using the 1764\u2010locus\n                    <jats:italic>Brucella<\/jats:italic>\n                    core\u2010genome multilocus sequence typing scheme. Across the eligible studies, reported crude seropositivity proportions ranged from 0.72% to 5.40% in humans and from 0.24% to 8.83% in animals. Molecular evidence included PCR positivity rates of 3.36% in goat vaginal swabs from Thailand and 39.2% in a selected mixed\u2010livestock population from Indonesia, together with the identification of\n                    <jats:italic>Brucella melitensis<\/jats:italic>\n                    ,\n                    <jats:italic>B. abortus<\/jats:italic>\n                    , and\n                    <jats:italic>B. suis<\/jats:italic>\n                    in several Southeast Asian countries. These findings provide epidemiological evidence of brucellosis in several countries. cgMLST analysis of the 24 available profiles from Malaysia and Thailand revealed close genetic relatedness among several isolates. Malaysian and Thai\n                    <jats:italic>B. melitensis<\/jats:italic>\n                    isolates differed by fewer than 11 alleles within the main cluster and by 41\u201381 alleles relative to isolates from India and the United Kingdom. Two Thai\n                    <jats:italic>B. abortus<\/jats:italic>\n                    isolates differed at only one locus and by 68\u2013150 alleles from isolates from Bangladesh, India, and Bolivia, whereas five Malaysian\n                    <jats:italic>B. suis<\/jats:italic>\n                    isolates differed by 7\u201378 alleles, indicating limited genetic diversity within the Malaysian cluster. Additional genomic and epidemiological data are needed to determine whether genetically similar isolates are epidemiologically linked. Brucellosis appears endemic in parts of Southeast Asia, but important gaps in published data remain. Integrated One Health surveillance is needed to improve regional risk assessment and control.\n                  <\/jats:p>","DOI":"10.1155\/tbed\/9792290","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:51:46Z","timestamp":1791287506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brucellosis in Southeast Asia: A Systematic Review of Epidemiological Evidence, Surveillance Gaps, and cgMLST\u2010Based Insights Into Genetic Relatedness"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1036-1320","authenticated-orcid":false,"given":"Qiuju","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Zoonosis Prevention and Control Yunnan Provincial Key Laboratory for Natural Focal Disease Control and Prevention Yunnan Institute of Endemic Disease Control and Prevention  Kunming 650500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-1297","authenticated-orcid":false,"given":"Xiaoan","family":"Cao","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Service Center State Key Laboratory of Animal Disease Control and Prevention Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences  Lanzhou 730046 China  caas.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Branch of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine  Beijing 102206 China  chinacdc.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Branch of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine  Beijing 102206 China  chinacdc.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Li","sequence":"additional","affiliation":[{"name":"Branch of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine  Beijing 102206 China  chinacdc.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6914-9825","authenticated-orcid":false,"given":"Zhiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Branch of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine  Beijing 102206 China  chinacdc.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001865"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2909.230052"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1259479"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2020.1868616"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00445"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010404"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.923657"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2023.2300965"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2025.l903"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/9966352"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00311-22"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.232397.117"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.09.016"},{"key":"e_1_2_13_14_2","first-page":"31","article-title":"Seroprevalance of Brucellosis Among Suspected Cases in Malaysia","volume":"33","author":"Jama\u2019ayah M. 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