{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:07:06Z","timestamp":1779797226513,"version":"3.53.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019904","name":"Vellore Institute of Technology, Chennai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Microbiota\u2010derived metabolites are increasingly recognized as modulators of systemic immunity and cancer biology. This study investigates how a structurally distinct lipid from\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                      influences immune transcriptional programs and their connection to breast cancer (BRCA)\u2010associated pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Donor\u2010adjusted reanalysis of PBMC RNA\u2010seq data was performed to identify lipid\u2010responsive transcriptional changes while minimizing interindividual variability. Differential expression was assessed across time points, followed by pathway enrichment and immune gene filtering. Immune cell composition was inferred using deconvolution analysis. Integration with The Cancer Genome Atlas (TCGA)\u2013BRCA datasets enabled tumor immune infiltration profiling and network\u2010based identification of hub genes. ceRNA interactions were refined using correlation\u2010supported datasets and prognostic relevance was evaluated in TCGA and METABRIC cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transcriptional variation was primarily driven by the treatment and exposure duration rather than donor effects. A biphasic immune response (IR) was observed, with early suppression followed by progressive activation. Lipid\u2010responsive genes significantly overlapped with BRCA immune signatures and were enriched in metabolic and stress\u2010related pathways. Immune deconvolution revealed shifts in macrophage polarization and cytotoxic cell populations. Network analysis identified key regulators, including ADIPOR1, KLF4, MYC, CXCL10, and ALDH1A1, linked to distinct immune infiltration patterns. ceRNA networks highlighted oncogenic and tumor\u2010suppressive miRNA interactions. A five\u2010gene signature demonstrated moderate prognostic value across cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microbial lipid signaling induces dynamic immune reprogramming that converges on tumor\u2010relevant pathways, suggesting a systemic immune\u2010mediated link between microbiota and BRCA progression, with potential implications for immune\u2010targeted therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tbj\/1416629","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:47:41Z","timestamp":1779796061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Akkermansia muciniphila<\/i>\n                    \u2013Driven ceRNA Networks Regulate Immune Modulation and Breast Cancer Progression"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-5172","authenticated-orcid":false,"given":"Uma","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5525-4371","authenticated-orcid":false,"given":"Arya","family":"A. 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