{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:47:09Z","timestamp":1782539229331,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate preoperative tumor size measurement is essential for determining optimal surgical margins in breast cancer patients. Thus, this study aimed to evaluate the factors associated with preoperative radiological tumor underestimation in clinical T (cT) Stage 1\u20132 breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the data of 365 cT1\u20132 breast cancer patients. Radiological tumor size was defined as the larger dimension on ultrasonography or magnetic resonance imaging. A pathological\u2010to\u2010radiological tumor size ratio &gt; 1.2 or a tumor size discrepancy (pathology minus radiology)\u2009\u2265\u20095\u2009mm was considered indicative of radiological underestimation. Preoperative variables, including age, body mass index (BMI), cT stage, maximum standardized uptake value of tumor, molecular subtype, and histologic subtype and grade, were analyzed to identify associated factors. Tumor size discrepancy (pathology minus radiology) was compared across subgroups, and the difference between pathological and radiological tumor size measurements was evaluated in each subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A BMI \u2265 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and invasive lobular carcinoma (ILC) histology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) were associated with a pathological\u2010to\u2010radiological tumor size ratio &gt; 1.2. A BMI \u2265 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), ILC histology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), and cT stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) were associated with a tumor size discrepancy (pathology minus radiology)\u2009\u2265\u20095\u2009mm. Significant differences in tumor size discrepancy between patients with a BMI \u2265 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and those with a BMI &lt; 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and between patients with an ILC and those with non\u2010ILC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) were observed. Bland\u2013Altman analysis showed radiological underestimation in ILCs (4.3\u2009mm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In cT1\u20132 breast cancer patients, a BMI \u2265 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and\/or an ILC are predictive of radiological tumor underestimation, warranting supplemental imaging and intraoperative margin assessment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tbj\/3726326","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:04:26Z","timestamp":1782536666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Preoperative Radiological Tumor Size Underestimation in Clinical T1\u20132 Breast Cancer Patients"],"prefix":"10.1155","volume":"2026","author":[{"given":"Jungbin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam-Youl","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Young","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Joo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongmee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7910-1052","authenticated-orcid":false,"given":"Geumhee","family":"Gwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13104"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10951"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0609-z"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.012"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14134806"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1742271x18804278"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03679-2"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-025-17663-5"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.4274\/ejbh.2020.5888"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102367"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.4274\/ejbh.galenos.2021.2021-4-7"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800138"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbi\/wbab015"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.10.1140"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14666"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0522-9"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2014.04.006"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.20.25223"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2011.10.008"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-328"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22290"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-019-0128-4"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-016-0103-7"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.3.1750805"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2018.09.004"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01678-y"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.Capr-11-0110"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-16-0150"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-46"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-09-3068"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2012.02.013"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc3175"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.17312"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.10.5556"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2010.02.005"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.4261\/1305-3825.Dir.598-06.3"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.15386\/mpr-1476"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/11782234221103504"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.08.1017"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.02.002"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103718"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14890"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.03.025"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1309\/ajcp4iemxcj1gdts"}],"container-title":["The Breast Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbj\/3726326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tbj\/3726326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tbj\/3726326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:04:28Z","timestamp":1782536668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tbj\/3726326"}},"subtitle":[],"editor":[{"given":"Sreeja","family":"Dattachoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/tbj\/3726326"],"URL":"https:\/\/doi.org\/10.1155\/tbj\/3726326","archive":["Portico"],"relation":{},"ISSN":["1075-122X","1524-4741"],"issn-type":[{"value":"1075-122X","type":"print"},{"value":"1524-4741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3726326"}}