{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:12:24Z","timestamp":1784790744599,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403399"],"award-info":[{"award-number":["82403399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Breast cancer is a leading female malignancy, with chronic inflammation driving progression. The IL\u20102\/IL\u20102R axis regulates immunity, but IL2RA\u2019s role in breast cancer (expression, diagnostic\/prognostic value, and interplay with IL\u20102) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 252 consecutive patients (99 breast cancer and 153 benign breast disease) who received breast surgery were retrospectively analyzed. Serum cytokines were measured via electrochemiluminescence immunoassay; ROC, single\u2010cell sequencing, and bioinformatics databases (TIMER and Kaplan\u2013Meier plotter) were used to assess IL2RA\/IL\u20102\u2019s utility and associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum IL2R\u03b1 was higher in breast cancer (336.9 vs. 275.8 U\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; no significant differences were observed for other cytokines). IL2R\u03b1 showed moderate diagnostic performance (AUC\u2009=\u20090.650, cut\u2010off\u2009=\u2009240.5 U\/mL), correlated with NLR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and showed a trend towards poor survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.124, HR\u2009=\u20090.309, 95% CI: 0.069\u20131.381). Single\u2010cell sequencing identified T cells as the primary source of IL2R\u03b1 in tumor tissues. High IL2RA expression strongly correlated with infiltration of immune cells, especially neutrophils (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.673) and dendritic cells (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.706). RNA\u2010seq analysis showed IL2RA was upregulated in tumor tissues, associated with poor prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20099.7\n                      <jats:italic>e<\/jats:italic>\n                      \u2009\u2212\u200906, HR\u2009=\u20091.29, 95% CI: 1.15\u20131.44) and aggressive features (e.g., lymph node metastasis and HER2 positivity). In contrast, IL\u20102 was highly expressed in normal tissues, linked to better prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001, HR\u2009=\u20090.83, 95% CI: 0.74\u20130.93), and had opposing clinical correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum IL2R\u0251 could serve as a complementary auxiliary diagnostic biomarker for breast cancer, with associations with systemic inflammation, immune cell infiltration, and aggressive disease. The functional antagonism between IL2RA and IL\u20102 highlights the IL\u20102\/IL2RA axis as a critical regulator of breast cancer pathophysiology, supporting its potential as a therapeutic target for improving breast cancer diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tbj\/5295439","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:41:13Z","timestamp":1784788873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum IL2R\u03b1 as a Diagnostic Biomarker and Its Functional Interplay With IL\u20102 in Breast Cancer"],"prefix":"10.1155","volume":"2026","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-029X","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-2986","authenticated-orcid":false,"given":"Yun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuning","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-5727","authenticated-orcid":false,"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/bctt.s176070"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx250"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0026"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062898"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.033"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.938556"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108515"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100123"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/13547500701674063"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1587"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211039590"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.02.001"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.22088\/cjim.14.3.479"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-17-0307"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0674-9"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1457-7"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.03.002"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn9083"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac022"},{"key":"e_1_2_10_21_2","first-page":"3046","article-title":"Changes in Plasma IL-1\u03b2, TNF-\u03b1 and IL-4 Levels Are Involved in Chemotherapy-Related Cognitive Impairment in Early-Stage Breast Cancer Patients","volume":"12","author":"Zhao J.","year":"2020","journal-title":"American Journal of Translational Research"}],"container-title":["The Breast 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