{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T18:44:39Z","timestamp":1777747479701,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ50305"],"award-info":[{"award-number":["2023JJ50305"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2023-18-88"],"award-info":[{"award-number":["320.6750.2023-18-88"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741278"],"award-info":[{"award-number":["2023M741278"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adipose tissue is a major stromal component of the breast cancer (BC) tumor microenvironment (TME), playing a crucial role in BC progression. Cancer\u2010associated adipocytes (CAAs), located at the invasive tumor front, undergo significant morphological and functional alterations. This observational case\u2013control study investigated the dedifferentiation trajectory of CAAs and its impact on BC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Paired tumor and distant normal adipose tissues from 20 BC patients were analyzed. Histological and immunohistochemical analyses were performed to assess morphological changes and marker expressions \u03b1\u2010SMA, S100A4, and CD36 in CAAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CAAs exhibited features consistent with dedifferentiation toward a myofibroblast\u2010like phenotype, marked by expressing \u03b1\u2010SMA and S100A4, indicators of myofibroblasts and tumor\u2010associated fibroblasts. Metabolically, CAAs showed increased CD36 expression and histological features compatible with augmented lipolysis and were spatially associated with areas of extracellular matrix (ECM) remodeling. Masson\u2019s trichrome staining demonstrated augmented pericellular collagen deposition, accompanied by increased tissue stiffness and enhanced angiogenesis at the tumor\u2013adipose boundary. In addition, nuclear translocation of \u03b2\u2010catenin in peritumoral adipocytes implicates the Wnt\/\u03b2\u2010catenin signaling axis as a potential regulator of adipocyte\u2013mesenchymal transition in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tbj\/5673713","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:46:22Z","timestamp":1777463182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer\u2010Associated Adipocytes in Human Breast Cancer: An Observational Histopathological Study of Dedifferentiation and Stromal Transition"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3224-7405","authenticated-orcid":false,"given":"Jun","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3705-5490","authenticated-orcid":false,"given":"Xiaomei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5581-0778","authenticated-orcid":false,"given":"Yichen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2466-1131","authenticated-orcid":false,"given":"Haibin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-0766","authenticated-orcid":false,"given":"Hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-0732","authenticated-orcid":false,"given":"Yiping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3323"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-1641"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06230-z"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65227"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0530"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060939"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-021-00324-7"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.09.002"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.36037"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650453"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111362"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.007759"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5611"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02108-4"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127201"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01650-5"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02408-z"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1525567"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0093-z"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0221-6"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00879-8"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013832"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00183-y"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1371"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20791"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03276-z"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.008"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5864"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147057"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29100"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.83"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33770"}],"container-title":["The 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