{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:47:27Z","timestamp":1791877647375,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":285,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20181196"],"award-info":[{"award-number":["20181196"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to compare and evaluate the dosimetric characteristics of five radiotherapy techniques in left\u2010sided breast cancer patients following breast\u2010conserving surgery. The five radiotherapy techniques include three\u2010dimensional conformal radiation therapy (3D\u2010CRT), fixed\u2010field intensity\u2010modulated radiation therapy (ff\u2010IMRT), volumetric modulated arc therapy (VMAT), hybrid 3D\u2010CRT with IMRT (CRT\u2009+\u2009IMRT), and hybrid 3D\u2010CRT with VMAT (CRT\u2009+\u2009VMAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Ten patients with left\u2010sided breast cancer who received postlumpectomy radiotherapy at the Department of Radiation Oncology, First Hospital of Qinhuangdao, between June 1, 2020, and June 1, 2021, were randomly enrolled in this study. For each patient, five distinct treatment plans were designed using the five aforementioned techniques (3D\u2010CRT, ff\u2010IMRT, VMAT, CRT\u2009+\u2009IMRT, and CRT\u2009+\u2009VMAT) based on identical computed tomography (CT) imaging datasets. Dosimetric parameters for the tumor target volume, organs at risk (OARs), and normal tissues (defined as body minus planning target volume [PTV], termed B\u2010P) were analyzed and compared using dose\u2013volume histograms (DVHs) and isodose distributions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CRT\u2009+\u2009VMAT technique demonstrated superior PTV dose coverage, conformity, and homogeneity compared to 3D\u2010CRT, ff\u2010IMRT, VMAT, and CRT\u2009+\u2009IMRT (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In contrast, the VMAT technique achieved significantly lower V\n                      <jats:sub>30<\/jats:sub>\n                      (%) values for bilateral lungs and ipsilateral lung than 3D\u2010CRT, ff\u2010IMRT, CRT\u2009+\u2009IMRT, and CRT\u2009+\u2009VMAT (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The CRT\u2009+\u2009IMRT technique reduced V\n                      <jats:sub>5<\/jats:sub>\n                      (%) values for bilateral lungs, ipsilateral lung, and heart compared to 3D\u2010CRT, ff\u2010IMRT, VMAT, and CRT\u2009+\u2009VMAT (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Finally, 3D\u2010CRT required the fewest monitor units (MUs) and shortest treatment time among all techniques (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinicians may tailor radiotherapy plans to individual patients based on the distinct dosimetric profiles of each technique. For patients requiring optimal PTV dose distribution, the CRT\u2009+\u2009VMAT technique is suggest. For enhanced cardiopulmonary protection (e.g., reduced lung\/heart doses), ff\u2010IMRT or CRT\u2009+\u2009IMRT may be prioritized. Additionally, 3D\u2010CRT should be the first choice for patients needing rapid fractionated treatment due to its efficiency in minimizing MUs and treatment time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tbj\/6666976","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:07:26Z","timestamp":1791875246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric Comparison of Five Radiotherapy Techniques in Left\u2010Sided Breast Cancer Patients Following Breast\u2010Conserving Surgery"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-0040","authenticated-orcid":false,"given":"Yanqiu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiotherapy First Hospital of Qinhuangdao  Qinhuangdao 066000 Hebei China  qhdsdyyy.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6064-438X","authenticated-orcid":false,"given":"A\u2019meng","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology Yanshan University  Qinhuangdao 066004 Hebei China  ysu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2415-2379","authenticated-orcid":false,"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy First Hospital of Qinhuangdao  Qinhuangdao 066000 Hebei China  qhdsdyyy.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0048-9929","authenticated-orcid":false,"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy First Hospital of Qinhuangdao  Qinhuangdao 066000 Hebei China  qhdsdyyy.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7453-7241","authenticated-orcid":false,"given":"Xiumei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy First Hospital of Qinhuangdao  Qinhuangdao 066000 Hebei China  qhdsdyyy.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2017.01.013"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2704"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00650"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211048706"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02319-5"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.02.025"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12767"},{"key":"e_1_2_12_8_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejmp.2018.06.641","article-title":"Hybrid Volumetric Modulated Arc Therapy for Chest Wall Irradiation: for a Good Plan, Get the Right Mixture","volume":"52","author":"Karunakaran B.","year":"2018","journal-title":"Physica Medica"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-019-00994-1"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02009-2"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2010.06.002"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/sajc.sajc_82_18"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/0284186x.2023.2238553"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(02)04617-5"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(97)00732-3"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4248-y"},{"key":"e_1_2_12_17_2","first-page":"15","article-title":"Assessment of Radiation Induced Pneumonitis and Pericarditis in Patients Undergoing Breast Conservative Treatment Using Hypofractionated Simultaneous Integrated Boost Technique","volume":"1","author":"Sundaramoorthy S.","year":"2024","journal-title":"Gulf J Oncolog"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.017"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/thc-160746"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000004609"},{"key":"e_1_2_12_21_2","first-page":"239","article-title":"Gated Radiotherapy Development and Its Expansion","volume":"11","author":"Keikhai Farzaneh M. 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