{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:22:03Z","timestamp":1787926923829,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":239,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972469"],"award-info":[{"award-number":["81972469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["YJSCX2025-58HYD"],"award-info":[{"award-number":["YJSCX2025-58HYD"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current treatment of triple\u2010negative breast cancer (TNBC) remains challenging; however, regulating ferroptosis through miRNAs offers new insights for TNBC treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bioinformatics methods were used to screen ferroptosis\u2010related differentially expressed genes (FRDEGs) in TNBC, and ferroptosis\u2010related miRNAs were screened by combining gene\u2010miRNA interaction network, miRNA survival analysis, and expression validation in clinical specimens. A nomogram was constructed to evaluate the prognostic impact of miR\u2010301a\u20103p in TNBC. Cell proliferation and migration capabilities were assessed using the CCK\u20108 assay, colony formation assay, and wound healing assay, respectively. The intracellular protein expression of GPX4 was measured by Western blot, and fluorescent probes were used to detect intracellular ROS and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study used bioinformatics methods to screen five FRDEGs in TNBC, thereby identifying six core miRNAs that can regulate these genes. Among these, miR\u2010301a\u20103p expression was significantly upregulated in tumor tissues compared to adjacent normal tissues and was associated with poor patient prognosis. Subsequently, an excellent prediction model was established using miR\u2010301a\u20103p expression information and patient clinicopathological information. Functional analyses revealed that miR\u2010301a\u20103p promoted TNBC cell proliferation and migration. In addition, the inhibition of cell proliferation activity by miR\u2010301a\u20103p inhibitor could be reversed by Ferrostatin\u20101, and miR\u2010301a\u20103p inhibitor could inhibit the expression of GPX4 and promote the accumulation of intracellular ROS and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      . The promotion of cell proliferation activity by miR\u2010301a\u20103p mimic could be reversed by Erastin, and miR\u2010301a\u20103p mimic could promote the expression of GPX4 and inhibit the accumulation of intracellular ROS and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, this study provides evidence that inhibition of miR\u2010301a\u20103p expression promotes ferroptosis in TNBC cells and produces a synergistic anti\u2010cancer effect with Erastin, providing a new target for future TNBC ferroptosis treatment strategies.<\/jats:p>\n                  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