{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:28:16Z","timestamp":1772987296224,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014563","name":"Universitas Andalas","doi-asserted-by":"publisher","award":["20\/UN16.19\/PT.01.03\/Pangan-RKLN\/2023"],"award-info":[{"award-number":["20\/UN16.19\/PT.01.03\/Pangan-RKLN\/2023"]}],"id":[{"id":"10.13039\/501100014563","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    This study investigated the effects of a combination of cassiavera and morel berry ethanol extracts (CMBEs) on diabetic rats, focusing on blood glucose levels, lipid profiles, immune and inflammatory markers, and pancreatic histopathology. Twenty male albino Wistar rats were divided into four groups: Group A (normal rats), Group B (diabetic rats), Group C (diabetic rats treated with metformin), and Group D (diabetic rats treated with CMBE). Parameters such as the IC\n                    <jats:sub>50<\/jats:sub>\n                    of CMBE, body weight, blood glucose levels, lipid profile, immune markers (leukocyte percentage, total count, and macrophage activity), inflammatory markers (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL\u20106), and pancreatic histopathology of rats were assessed for 7 weeks. Statistical analysis was performed using one\u2010way analysis of variance followed by Duncan\u2019s multiple range test, with a significance level of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 5\n                    <jats:italic>%<\/jats:italic>\n                    . The results revealed an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 18.5338\u2009ppm for CMBE. Weight gain was observed in all groups except Group B, in which rats lost weight. CMBE was notably effective in lowering blood glucose levels in diabetic rats, with rats in Group D exhibiting higher HDL cholesterol levels and total leukocyte counts compared with those in Group C. Furthermore, CMBE significantly reduced TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL\u20106 levels, exhibiting promising potential in promoting pancreatic repair. This study highlights the potential of a combination of Cassiavera and Morel Berry extract as an effective antidiabetic agent, suggesting it as a valuable addition to functional food formulations.\n                  <\/jats:p>","DOI":"10.1155\/tswj\/1526410","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:17:27Z","timestamp":1747725447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antidiabetic Potential of Combined Cassiavera and Morel Berry Ethanol Extracts in Diabetic Rats"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3861-5906","authenticated-orcid":false,"given":"Fauzan","family":"Azima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-0499","authenticated-orcid":false,"given":"Wan Rosli Wan","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-9486","authenticated-orcid":false,"given":"Daimon","family":"Syukri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0445-5012","authenticated-orcid":false,"family":"Rahmayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4477-6062","authenticated-orcid":false,"given":"Muhammad","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9055-1661","authenticated-orcid":false,"given":"Yasmin","family":"Azzahra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13306"},{"key":"e_1_2_11_2_2","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2021"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081987"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05618-w"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2020.12.87"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/388"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.08.045"},{"key":"e_1_2_11_8_2","first-page":"30","article-title":"Effect of Physalins on the Modulation of NF-kB and Its Possible Implications for Glucose Homeostasis","volume":"5","author":"Pequeno A.","year":"2017","journal-title":"International Journal of Herbal Medicine"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods12142742"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.13189\/fst.2024.120102"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762007005000066"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-022-02422-z"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3923\/ajps.2022.735.739"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/709\/1\/012017"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/515\/1\/012021"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S234665"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72350"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3923\/ajps.2023.567.574"},{"key":"e_1_2_11_19_2","first-page":"1","article-title":"Histopathological Evaluation of the Pancreas Following Administration of Paricalcitol in Alloxan-Induced Diabetic Histopathological Evaluation of the Pancreas Following Administration of Paricalcitol in Alloxan-Induced Diabetic Wistar Rats","volume":"5","author":"El-Esawy B. 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