{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:57:53Z","timestamp":1777355873037,"version":"3.51.4"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":116,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012958","name":"Minist\u00e8re de l'Education Nationale, de la Formation professionnelle, de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The ethnopharmacological relevance of\n                      <jats:italic>Dysphania ambrosioides<\/jats:italic>\n                      (commonly known as M\u2019khinza) is evident in its longstanding traditional use across various cultures, where it is valued for its medicinal properties in addressing a range of health conditions, emphasizing the potential for further pharmacological exploration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The present study aims to investigate the cardioprotection against ischemia\u2013reperfusion (IR) injuries following the administration of aqueous extract (Aq.E) of\n                      <jats:italic>D. ambrosioides<\/jats:italic>\n                      leaves in isolated rat hearts according to\n                      <jats:italic>Langendorff<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The hearts of male Wistar rats were isolated, allowed to acclimate for 30\u2009min, and then experienced global ischemia for 30\u2009min and reperfusion for 120\u2009min. Krebs\u2013Henseleit buffer (KHB) was infused into the control group. However, a solution with 10, 20, and 40\u2009\u00b5g\/mL of extract was infused into the treatment groups (KHB). The Aq.E anti\u2010inflammatory, anticoagulant, and antioxidant properties were also assessed, and its mineral composition was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate that the\n                      <jats:italic>D. ambrosioides<\/jats:italic>\n                      leaf Aq.E has considerable cardioprotective activity, evidenced by its beneficial hemodynamic, biochemical, and histological effects in mitigating myocardial lesions induced by the IR sequence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings from this study indicate that the\n                      <jats:italic>D. ambrosioides<\/jats:italic>\n                      leaf Aq.E provides cardioprotective benefits in the context of IR injury. This protective effect is attributed to the extract\u2019s antioxidant, anti\u2010inflammatory, and anticoagulant properties, as evidenced by significant hemodynamic, biochemical, and histological improvements. These findings highlight the potential of\n                      <jats:italic>D. ambrosioides<\/jats:italic>\n                      as a medicinal substance for preserving cardiac function and integrity during ischemic events.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tswj\/2570536","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:24:02Z","timestamp":1777353842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotective Effects of\n                    <i>Dysphania ambrosioides<\/i>\n                    Leaves Against Ischemia\/Reperfusion\u2010Induced Myocardial Injury in Langendorff\u2010Perfused Rat Heart"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-0991","authenticated-orcid":false,"given":"Mounime","family":"Kadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-3516","authenticated-orcid":false,"given":"Ali","family":"Berraaouan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-9588","authenticated-orcid":false,"given":"Hassane","family":"Mekhfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-2537","authenticated-orcid":false,"given":"Abderrahim","family":"Ziyyat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-1290","authenticated-orcid":false,"given":"Mohamed","family":"Bnouham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-9429","authenticated-orcid":false,"given":"Abdelkhaleq","family":"Legssyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2019v11i2.30387"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9441"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/974358"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62874"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/864946"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.2.101"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.4.381"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119452"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5871"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.79.5.949"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874120701007010001"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13636"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1520-037x.2000.80355.x"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(97)00077-9"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.54250\/ijls.v2i2.42"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/930208"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.03.016"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2019.1588171"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1437428"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2019.01.006"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.08.237"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1087"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2017.0011"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.06.068"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.018"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.54250\/ijls.v2i2.42"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2019v11i2.30387"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.22159\/ijcpr.2017v9i5.22130"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(79)90064-1"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(03)00119-3"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070840"},{"key":"e_1_2_13_32_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/B978-0-12-091302-2.50032-3","volume-title":"Methods of Enzymatic Analysis","author":"Aebi H.","year":"1974"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003697"},{"key":"e_1_2_13_34_2","first-page":"302","volume-title":"Methods in Enzymology","author":"Buege J. A.","year":"1978"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(03)00432-6"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14047370"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2013.08.008"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016110790226561"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2002.01728.x"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000159116"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969609081773"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.6.2_pt_2.i170"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.098251"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23392"},{"key":"e_1_2_13_46_2","doi-asserted-by":"crossref","unstructured":"WinZ.andOoS. S. Investigation of Elemental Concentration on Tha-Na-Kha Flower and Their Utilization MERAL Portal https:\/\/doi.org\/10.1016\/j.jqsrt.2006.02.021 2-s2.0-33747374096.","DOI":"10.1016\/j.jqsrt.2006.02.021"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(84)80021-3"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/17429145.2015.1056260"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000232617.48372.cb"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000232617.48372.cb"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2015.07.044"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/805756"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants7010022"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308601750100506"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.766"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1724194"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.71.e120886"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613491458"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.02.032"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2019.1100761"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2017.0011"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384718"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.256.5.H1344"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.81.1.201"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.81.1.201"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-016-0510-8"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301527"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.6.H2025"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.027482"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.016"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(78)91148-0"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/2570536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tswj\/2570536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/2570536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:24:12Z","timestamp":1777353852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tswj\/2570536"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/tswj\/2570536"],"URL":"https:\/\/doi.org\/10.1155\/tswj\/2570536","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2570536"}}