{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:12:09Z","timestamp":1789798329667,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Introduction<\/jats:title>\n \n Bio\u2010Immune is a standardized extract containing andrographolide, a diterpenoid lactone derived from the aerial parts of\n Andrographis paniculata<\/jats:italic>\n (commonly known as Kalmegh), and the carrier, 2\u2010hydroxypropyl beta\u2010cyclodextrin. Kalmegh has long been used to treat uncomplicated upper respiratory tract infection (URTI) in complementary and alternative medicine. A randomized, double\u2010blind, placebo\u2010controlled clinical trial was conducted to evaluate the efficacy of Bio\u2010Immune (\u2265\u200917%\n w<\/jats:italic>\n \/\n w<\/jats:italic>\n andrographolide content).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Participants were randomized to receive either 100\u2009mg Bio\u2010Immune twice daily or placebo for a 5\u2010day intervention period (Clinical trial registration number: CTRI\/2024\/12\/077632, Registered 4, December 2024). The primary outcome measure was the Wisconsin Upper Respiratory Symptom Survey\u201021 (WURSS\u201021) score; secondary outcomes included Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) scores, nasal mucus weight, C\u2010reactive protein (CRP), Interleukin\u20108 (IL\u20108), and Immunoglobulin A (IgA) in nasal wash, along with safety.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 67 screened participants, 56 were enrolled, and 55 completed the study. The WURSS\u201021, VAS, and NRS scores in the Bio\u2010Immune group improved, with statistically significant reductions suggesting relief from symptoms associated with uncomplicated URTI and sustained functional improvement owing to Bio\u2010Immune supplementation. Although the placebo group showed gradual improvement over time, the speed and magnitude of recovery were consistently and statistically superior in the Bio\u2010Immune cohort, with significant changes evident by 6\u2009h after supplementation. Furthermore, a significant reduction in nasal mucus weight was observed by Day 5, accompanied by minor downward trends in CRP and IL\u20108, which lacked adequate statistical support. No adverse events were reported during the intervention period.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Clinical findings support the efficacy of Bio\u2010Immune at a lower dose in providing URTI symptom relief compared with placebo in a shorter intervention period.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Clinical Trial Registry of India: CTRI\/2024\/12\/077632; ClinicalTrials.gov identifier: NCT06689995<\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/tswj\/2916630","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:35:36Z","timestamp":1789796136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Safety and Efficacy of Bio\u2010Immune (Andrographolide) in Managing URTI Symptoms: A Randomized, Double\u2010Blinded, Placebo\u2010Controlled, Single\u2010Center, Comparative Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-429X","authenticated-orcid":false,"given":"Shashi Chandrama","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6854-7715","authenticated-orcid":false,"given":"Muskan","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9941-8682","authenticated-orcid":false,"given":"Khushi","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6726-7255","authenticated-orcid":false,"given":"Harsh Pal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_13_1_2","volume-title":"StatPearls","author":"Tobin E. H.","year":"2025"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-370879-6\/00416-6"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2023.102934"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.4308\/hjb.22.2.67"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/life11040348"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2003.00534.x"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650090804"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.12.001"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07741"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-019-00169-0"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-016-0635-y"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6224107"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/2916630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tswj\/2916630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/2916630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:35:37Z","timestamp":1789796137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tswj\/2916630"}},"subtitle":[],"editor":[{"given":"Deepali","family":"Deepali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/tswj\/2916630"],"URL":"https:\/\/doi.org\/10.1155\/tswj\/2916630","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2916630"}}