{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:27:48Z","timestamp":1786624068555,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":224,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Anxiety and depression are significant neurological disorders with limited treatment efficacy and notable side effects associated with conventional synthetic drugs. This study investigated the anxiolytic and antidepressant potential of the methanolic leaf extract of\n                    <jats:italic>Drimycarpus racemosus<\/jats:italic>\n                    Hook. f. (MEDR) using both in vivo behavioral models and in silico molecular docking approaches. GC\u2013MS analysis of MEDR identified 39 phytochemical constituents, including bioactive terpenoids, phenolic compounds, and fatty acid esters. In vivo experiments were conducted (\n                    <jats:italic>n<\/jats:italic>\n                    = 5 per group) on Swiss albino mice randomly divided into control, standard (diazepam 1\u2009mg\/kg), and treatment groups receiving MEDR (200 and 400\u2009mg\/kg) using the elevated plus maze (EPM), hole\u2010board test (HBT), light\u2013dark box (LDB), and forced swim test (FST). MEDR exhibited significant dose\u2010dependent effects. At 400\u2009mg\/kg, MEDR significantly increased time spent in the open arms of the EPM by approximately 89% (140.0 \u00b1 1.79\u2009s vs. 74.2 \u00b1 2.71\u2009s in control, \u2217\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and number of open\u2010arm entries (17.2 \u00b1 1.43 vs. 10.4 \u00b1 1.57) while markedly reducing immobility time in the FST by ~44% (102.2 \u00b1 1.16\u2009s vs. 182.6 \u00b1 1.94\u2009s in control, \u2217\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). These effects were comparable to the standard drug diazepam (1\u2009mg\/kg). Molecular docking studies against the potassium channel (PDB ID: 4UUJ), GABAA receptor (PDB ID: 6X3X), and human serotonin transporter (hSERT, PDB ID: 5I6X) revealed that\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol acetate and 2\u2010[4\u2010cyclohexylbutanoylamino]\u20103\u2010chloro\u20101,4\u2010naphthoquinone exhibited higher binding affinities than diazepam across all three targets. The combined in vivo and in silico findings indicate that\n                    <jats:italic>D. racemosus<\/jats:italic>\n                    exerts multitarget neuropharmacological effects, primarily through modulation of GABAergic and serotonergic systems. These results highlight the phytochemical richness and therapeutic promise of MEDR as a potential source for developing safe, plant\u2010based neurotherapeutics for anxiety and depression.\n                  <\/jats:p>","DOI":"10.1155\/tswj\/7306249","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:31:46Z","timestamp":1786620706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multitarget Neuropharmacological Actions of\n                    <i>Drimycarpus racemosus<\/i>\n                    Hook. f. GC\u2013MS\u2010Guided In Vivo and In Silico Evidence of Anxiolytic and Antidepressant Potential"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1146-5312","authenticated-orcid":false,"given":"Md. Rakibul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2252-1818","authenticated-orcid":false,"given":"Md. Sajib","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6710-7781","authenticated-orcid":false,"given":"Priota Islam","family":"Meem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7710-0383","authenticated-orcid":false,"given":"M. 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