{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:43:47Z","timestamp":1776077027233,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":102,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Streblus asper<\/jats:italic>\n                    (Moraceae) is traditionally used for neurological and febrile disorders, but its pharmacological basis remains unclear. This study evaluated the\n                    <jats:italic>S. asper<\/jats:italic>\n                    leaf methanolic extract (SAL\u2010ME) for anxiolytic, antidepressant, sedative, and antipyretic activities using Swiss albino mice and in silico docking analyses. Behavioral assays included the elevated plus maze, hole\u2010board, forced swim, tail suspension, hole cross, and open field tests, while brewer\u2019s yeast\u2010induced pyrexia was used to assess antipyretic activity. SAL\u2010ME (200 and 400\u2009mg\/kg) produced dose\u2010dependent effects, significantly reducing immobility time (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), increasing open\u2010arm exploration (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), and suppressing locomotor activity, indicating antidepressant, anxiolytic, and sedative actions. A significant antipyretic effect was observed at 400\u2009mg\/kg, with a marked reduction in rectal temperature within 3\u2009h posttreatment (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Molecular docking analysis revealed notable binding affinities of octadecanoic acid, hexadecanoic acid, D\u2010pinitol, \u03b1\u2010D\u2010glucopyranoside, myo\u2010inositol, and butanedioic acid with target proteins associated with GABAergic, serotonergic, and prostaglandin\u2010mediated pathways. Collectively, these findings suggest that SAL\u2010ME exerts dose\u2010dependent, multitarget pharmacological effects, supporting its potential as a phytotherapeutic candidate for CNS disorders and fever.\n                  <\/jats:p>","DOI":"10.1155\/tswj\/7661411","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:47:46Z","timestamp":1776073666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropharmacological and Antipyretic Potentials of\n                    <i>Streblus asper<\/i>\n                    Leaves: Integrated In Vivo and In Silico Approaches"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9514-1601","authenticated-orcid":false,"given":"Md. 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