{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:13:33Z","timestamp":1778307213164,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":127,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Routinely, the focus of pre\u2013assisted reproduction technology (ART) assessments is ovarian reserve hormones and semen parameters. However, a growing body of research suggests that systemic metabolic health is a critical determinant of reproductive outcomes. The study therefore sought to evaluate disparities in baseline cardiometabolic, hepatic, renal and haematologic factors in infertile women and their pregnancy status following the ART procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional baseline assessment with prospective follow\u2010up study was conducted at The Chosen Hospital and Fertility Centre in Accra, Ghana, from January 2024 to March 2025. The study involved 206 infertile women aged from 28 to 60 years. Venous blood samples were collected and analysed for fasting lipids, complete blood count and renal and liver function, before any ART procedure. The pregnancy status of women was determined after the ART procedure as either positive or negative, and whether their infertility type was primary, secondary or subfertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the multivariable analysis, the chloride level was 0.164\u2009mmol\/L higher in women who achieved post\u2010ART pregnancy with an adjusted odds ratio (95% CI) of 1.179 (1.017\u20131.366). The proportion of eosinophils was higher in subfertility than in primary infertility (3.7 \u00b1 1.8 vs. 2.3 \u00b1 1.5,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.050). In addition, the mean platelet volume (10.4 \u00b1 1.8 vs. 9.8 \u00b1 1.5 vs. 8.3 \u00b1 1.1,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.050) and the platelet distribution width (13.3 \u00b1 3.0 vs. 12.4 \u00b1 2.7 vs. 9.9 \u00b1 1.8,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.050) were higher in secondary infertility than primary and subfertility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a routinely available and inexpensive biomarker, serum chloride could enhance pre\u2010ART assessment if confirmed in larger prospective studies. The MPV, PDW and eosinophil proportion across infertility types may be indicators of distinct underlying pathophysiological pathways in different infertility diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/tswj\/7976886","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:52:08Z","timestamp":1778305928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline Cardiometabolic, Hepatic and Renal Profile of Infertile Women and Pregnancy Status Following Assisted Reproduction Technology Procedure"],"prefix":"10.1155","volume":"2026","author":[{"given":"Isaac Kofi","family":"Adu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3035-9292","authenticated-orcid":false,"given":"Victor Boachie","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric K.","family":"Amoako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon N. A.","family":"Attoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel K.","family":"Asiedu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-6077","authenticated-orcid":false,"given":"Moses","family":"Banyeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-1523","authenticated-orcid":false,"given":"Issah Zabsonre","family":"Alhassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafiu","family":"Amidu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_13_1_2","unstructured":"WHO Infertility Prevalence Estimates 1990\u20132021 World Health Organization 2023."},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-025-01966-7"},{"key":"e_1_2_13_4_2","first-page":"1","volume-title":"Handbook of Social Sciences and Global Public Health","author":"Hawkey A.","year":"2023"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40834-023-00225-z"},{"key":"e_1_2_13_6_2","first-page":"32","article-title":"Living in a Man\u2032s World: An Exploratory Study of the Experiences of Ghanaian Women With Infertility Problems","volume":"19","author":"Hiadzi R. A.","year":"2022","journal-title":"Ghana Social Science Journal"},{"key":"e_1_2_13_7_2","first-page":"249","article-title":"WHO Fact Sheet on Infertility Gives Hope to Millions of Infertile Couples Worldwide","volume":"12","author":"Ombelet W.","year":"2020","journal-title":"Facts, Views & Vision in ObGyn"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.12.041"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13133739"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-025-01043-y"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1513358"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00871-y"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i11.1611"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105439"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00237-0"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaf097.995"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology11071006"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu006"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.046"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.08.850"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9213074"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417336"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221435"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13092147"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/7976886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/tswj\/7976886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/tswj\/7976886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:52:12Z","timestamp":1778305932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/tswj\/7976886"}},"subtitle":[],"editor":[{"given":"Vikram","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/tswj\/7976886"],"URL":"https:\/\/doi.org\/10.1155\/tswj\/7976886","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7976886"}}