{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:29:01Z","timestamp":1772987341763,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Peripheral neuropathic pain (PNP) is a significant complication for diabetic patients, often linked to poor glycemic control and elevated levels of glycosylated hemoglobin (HbA1c). High serum levels of cytokines, such as interleukin (IL)\u20106, and an increase in T\u2010lymphocytes are crucial factors in developing neuropathic complications. Research suggests that substances like opiates and methadone can provide pain relief for these patients. This literature review is aimed at exploring the advantages and disadvantages of prescribing methadone to individuals with diabetes. We conducted a search of several databases, including PubMed, Google Scholar, Medline, Embase, Web of Science, and Scopus. We used keywords such as \u201cdiabetes,\u201d \u201cneuropathic pain,\u201d \u201cmethadone,\u201d \u201copioids,\u201d \u201cinflammation,\u201d and \u201cneuroimmunomodulation.\u201d Ultimately, we identified 19 articles suitable for a more detailed examination. Studies have revealed that the visual analog scale (VAS) index and serum glucose levels decreased in patients who had taken low\u2010dose methadone. Additionally, the production of N\u2010chlorotaurine, a crucial component for innate immunity, was increased in these individuals. Methadone, in a dose\u2010dependent manner, is accountable for increasing serum levels of tumor necrosis factor alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), interleukin\u20101 beta (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ), and interleukin\u20102 (IL\u20102) and a high number of monocyte CD14\n                    <jats:sup>+<\/jats:sup>\n                    . In conclusion, there were several advantages to taking methadone in a dose\u2010dependent manner, compared to opioids.\n                  <\/jats:p>","DOI":"10.1155\/tswj\/8483881","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:33:40Z","timestamp":1741732420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Review of the Prospective Effects of Methadone on Peripheral Neuropathic Pain in Diabetic 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