{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:06:42Z","timestamp":1775038002597,"version":"3.50.1"},"reference-count":93,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The focus of recent research has been on developing natural medicines. Natural substances of the\n                    <jats:italic>Annona reticulata<\/jats:italic>\n                    Linn. plant, which belongs to the\n                    <jats:italic>Annonaceae<\/jats:italic>\n                    family, have medicinal uses. The antibacterial, insecticidal, and antidiarrheal properties of\n                    <jats:italic>Annona reticulata<\/jats:italic>\n                    Linn. methanol and aqueous leaf fractions were assessed in this study along with phytochemical screening and GC\u2013MS analysis. Both extracts\u2019 antibacterial properties were evaluated at a dosage of 250\u2009mg\/mL using the disc diffusion method. While the zones of inhibition values for aqueous extract were lower than those for methanol extract, the zones of inhibition values for methanol leaf extract against specific gram\u2010positive and gram\u2010negative bacterial strains were almost equivalent to those obtained from the standard drug tetracycline hydrochloride. The methanol extract showed strong insecticidal potential against\n                    <jats:italic>T. castaneum<\/jats:italic>\n                    and\n                    <jats:italic>P. americana<\/jats:italic>\n                    , which was found to be even more effective than the standard permethrin solution. Additionally, the aqueous leaf extract showed good insecticidal activity; however, it was less effective than the methanolic extract. Castor oil\u2013induced diarrhea test was utilized for assessment of antidiarrheal potentials; at dosages of 200 and 400\u2009mg\/kg of body weight, methanol and aqueous fractions showed significant outcomes with notable onset of diarrhea and total quantity of feces values (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Both methanol and aqueous leaf fractions demonstrated percentage inhibition of diarrhea values of 44.19% and 41.86%, respectively, at a 400\u2009mg\/kg dosage. In the enteropooling test, the castor oil\u2013induced intestinal volume was also significantly (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) decreased by both methanol and aqueous extracts. Furthermore, intestinal transit was inhibited by aqueous and methanol extracts by 50.89% and 52.78%, respectively, at a 400\u2009mg\/kg dosage in GI motility tests. The outcomes significantly resembled those of the standard drug loperamide (5\u2009mg\/kg). Plant extracts were screened for certain phytochemicals using a preliminary phytochemical screening assay. GC\u2013MS analysis was utilized for the determination of the chemical constituents that were responsible for achieving these activities.\n                  <\/jats:p>","DOI":"10.1155\/tswj\/9100797","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:49:34Z","timestamp":1775029774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Therapeutic Spectrum of\n                    <i>Annona reticulata<\/i>\n                    Linn.: Antibacterial, Insecticidal, and Antidiarrheal Insights"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2104-2579","authenticated-orcid":false,"given":"Tasnia Binte","family":"Bari Kabbo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Sohel","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goutam Kumar","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8779-9550","authenticated-orcid":false,"given":"Pritesh Ranjan","family":"Dash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/B978-0-323-91099-6.00005-0","article-title":"Insight into Coronaviruses and Natural Products-based Approach for COVID-19 Treatment","volume":"74","author":"Suresh P. 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