{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:25:27Z","timestamp":1787307927359,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":232,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303671\/2019\u20130"],"award-info":[{"award-number":["303671\/2019\u20130"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311128\/2023\u20138"],"award-info":[{"award-number":["311128\/2023\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["0001"],"award-info":[{"award-number":["0001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Mycobacteria infection is a serious public health problem and has been described as causing diseases in domestic animals. The objective of this study was to evaluate the immunopathogenesis of\n                    <jats:italic>Mycobacterium avium<\/jats:italic>\n                    subspecies\n                    <jats:italic>hominissuis<\/jats:italic>\n                    isolated from a domestic cat in mice. Mice were intravenously infected with 10\n                    <jats:sup>6<\/jats:sup>\n                    \u2009CFU, and the spleen, lung, liver, and submandibular glands were collected for a histopathology study and bacillary load evaluation. Lung cells, such as macrophages, NK1.1\u2009cells, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes were evaluated by flow cytometry. The infection spread to the liver, lungs, lymph nodes, and submandibular salivary gland, causing severe necrotic lesions and inducing increased levels of lung macrophages, NK, and dendritic cells, as well as specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes. Thus,\n                    <jats:italic>Mycobacterium avium<\/jats:italic>\n                    subsp\n                    <jats:italic>. hominissuis<\/jats:italic>\n                    presented here induced pathogenicity and immune responses in the mouse model, as other mycobacterial infections, indicating that this bacterium could induce serious disease in animals.\n                  <\/jats:p>","DOI":"10.1155\/vmi\/7207350","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:41:39Z","timestamp":1787305299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Virulence of\n                    <i>Mycobacterium avium<\/i>\n                    Subsp.\n                    <i>hominissuis<\/i>\n                    Isolated From Feline Thyroid and Pancreatic Tissues in a Murine Infection Model"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-8613","authenticated-orcid":false,"given":"Adeliane Castro da","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-8444","authenticated-orcid":false,"given":"F\u00e1bio Muniz de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-480X","authenticated-orcid":false,"given":"Fabr\u00edcio","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-0044","authenticated-orcid":false,"given":"L\u00e1zaro Moreira","family":"Marques-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-4833","authenticated-orcid":false,"given":"\u00cdsis Assis","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-6507","authenticated-orcid":false,"given":"Danieli Brolo","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-106X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-6617","authenticated-orcid":false,"given":"Ana Paula","family":"Junqueira-Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13102329"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-58"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638717713795"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045411"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.g2338"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01869-09"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00036-06"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2017.04.008"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2014.08.007"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171895"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.02.014"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1406.071463"},{"key":"e_1_2_11_13_2","first-page":"74","volume-title":"Mycobacterium avium Subspecies hominissuis Infection in a Domestic European Shorthair Cat","author":"Klang A.","year":"2014"},{"key":"e_1_2_11_14_2","volume-title":"Elucidation of Canine Immune Response to Mycobacterium avium Complex Infection [Master\u2019s Thesis]","author":"Kim S.","year":"2022"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00347-08"},{"key":"e_1_2_11_16_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1099\/ijs.0.63969-0","article-title":"rpoB Gene Sequence-Based Characterization of Emerging Non-tuberculous Mycobacteria With Descriptions of Mycobacterium bolletii sp. Nov., Mycobacterium phocaicum sp. Nov. and Mycobacterium aubagnense sp. Nov","volume":"56","author":"Ad\u00e9kambi T.","year":"2006","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112848"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.07.001"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803329"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20010934"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6039"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2012.01.004"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200573"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2012.01352.x"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165x.1997.tb00716.x"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0108.x"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.l5594"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.04841-14"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0492"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1578082"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-5845-4"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100130610"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01795"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-3-213"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.09.014"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.5.710-a"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00169-11"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.84"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0230-2016"}],"container-title":["Veterinary Medicine International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/vmi\/7207350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/vmi\/7207350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/vmi\/7207350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:41:41Z","timestamp":1787305301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/vmi\/7207350"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/vmi\/7207350"],"URL":"https:\/\/doi.org\/10.1155\/vmi\/7207350","archive":["Portico"],"relation":{},"ISSN":["2090-8113","2042-0048"],"issn-type":[{"value":"2090-8113","type":"print"},{"value":"2042-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7207350"}}