{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:57:07Z","timestamp":1785268627507,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["171\/UN3.LPPM\/PT.01.03\/2024"],"award-info":[{"award-number":["171\/UN3.LPPM\/PT.01.03\/2024"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The proliferation of\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    with extended\u2010spectrum beta\u2010lactamase (ESBL), including\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    , poses a significant threat to public health due to their resistance to \u03b2\u2010lactam antibiotics. This study focuses on the risk factors of ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    in the wastewater of dairy farms in East Java, Indonesia, a major milk\u2010producing region. Utilizing an observational cross\u2010sectional design, data were collected from 342 wastewater samples across six regions with high dairy cattle populations in East Java. Risk factors were assessed through questionnaires addressing variables related to farmers and farm management. Univariate analysis by regency\/city identified several significant risk factors for the occurrence of ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    in dairy farm wastewater in East Java, and it differed between regencies\/cities. Multivariate analysis of risk factors that significantly correlated with ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    showed a distance of \u2264 10\u2009m between septic tanks and wells that significantly increased the risk of ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    occurrence (OR 3.24, 95% CI: 1.07\u20139.80), as did not using detergent for barn cleaning (OR 2.67, 95% CI: 1.23\u20135.67). Conversely, the use of water storage tanks and a distance of \u2264 500\u2009m from other dairy farms appeared to reduce the risk. This study provides critical insights for developing strategies to control and prevent antibiotic resistance in the dairy farming sector, such as improved wastewater management, stricter regulations on antibiotic usage, and enhanced farmer education programs. Implementing these strategies is crucial to mitigating the spread of ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    , thereby improving public and environmental health in East Java.\n                  <\/jats:p>","DOI":"10.1155\/vmi\/8706598","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T06:45:00Z","timestamp":1757659500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk Factors for ESBL\u2010Producing\n                    <i>Enterobacteriaceae<\/i>\n                    in Wastewater of Dairy Farms in East Java, Indonesia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-1073","authenticated-orcid":false,"given":"Fidi Nur Aini Eka Puji","family":"Dameanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-1104","authenticated-orcid":false,"given":"Sheila Marty","family":"Yanestria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-411X","authenticated-orcid":false,"given":"Mustofa Helmi","family":"Effendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4932-7463","authenticated-orcid":false,"given":"Wiwiek","family":"Tyasningsih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-811X","authenticated-orcid":false,"given":"Hani","family":"Plumeriastuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-481X","authenticated-orcid":false,"given":"Emmanuel Nnabuike","family":"Ugbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-0222","authenticated-orcid":false,"given":"Rahayu","family":"Sutrisno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7244-8372","authenticated-orcid":false,"given":"Muhammad Ali Akramsyah","family":"Safri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.13057\/biodiv\/d230911"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025247"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.36899\/JAPS.2021.4.0289"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.5398\/tasj.2021.44.1.10"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93201-z"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wasman.2015.01.027"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2012.11.027"},{"key":"e_1_2_10_8_2","unstructured":"Bps-Statistics of Jawa Timur Province Jawa Timur Province in Figures 2023 BPS-Statistics of Jawa Timur Province Surabaya 2023."},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.13057\/biodiv\/d231002"},{"key":"e_1_2_10_10_2","first-page":"1350","volume-title":"Science","author":"van Boeckel T. 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