{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:42:10Z","timestamp":1782495730669,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":219,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate whether intravenous administration of dexmedetomidine alters the electrocardiographic parameters of healthy dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals:<\/jats:bold>\n                    22 healthy dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Study Design:<\/jats:bold>\n                    prospective blind clinical trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    The dogs underwent electrocardiographic monitoring at two moments: baseline moment (MB), subjected to tranquilization with butorphanol (0.25\u2009mg\/kg\/IM), and dexmedetomidine moment (MDEX), after 10\u2009min of intravenous administration of dexmedetomidine (bolus of 2\u2009\u03bcg\/kg, in 2\u2009minutes, followed by continuous infusion at a rate of 2\u2009\u03bcg\/kg\/hour).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    After intravenous administration of dexmedetomidine, sinus bradycardia predominated. Regarding electrocardiographic parameters, there was a significant increase in the duration of the P wave (44; 51\u2009ms), QRS complex (62; 67\u2009ms), PR interval (95; 126\u2009ms), and QT interval (207; 252\u2009ms) and reduction in the QTc interval (249; 226\u2009ms), without significant change in systolic, mean, and diastolic blood pressure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Intravenous administration of dexmedetomidine in healthy dogs results in increased parasympathetic tone with significant reduction in heart rate and increased conduction time of electrical impulses in the myocardium.\n                  <\/jats:p>","DOI":"10.1155\/vmi\/9947159","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T21:18:34Z","timestamp":1754687914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dexmedetomidine in Healthy Dogs: Impact on Electrocardiographic Parameters"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3608-8329","authenticated-orcid":false,"given":"Guilherme Andraus","family":"Bispo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2131-2174","authenticated-orcid":false,"given":"Thais","family":"Cabral de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-7048","authenticated-orcid":false,"given":"Marcela Fernanda","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-1898","authenticated-orcid":false,"given":"Matheus Fujimura","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-7366","authenticated-orcid":false,"given":"Lais Calazans Menescal","family":"Linhares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0276-0764","authenticated-orcid":false,"given":"Nat\u00e1lia Sena Nascimento de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0441-0872","authenticated-orcid":false,"given":"Ana Kelly Sousa da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-3461","authenticated-orcid":false,"given":"Marilda Onghero","family":"Taffarel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-3917","authenticated-orcid":false,"given":"Wagner Lu\u00eds","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-5569","authenticated-orcid":false,"given":"Paulo Sergio Patto dos","family":"Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani10071240"},{"key":"e_1_2_10_2_2","article-title":"Dexmedetomidine Sedation in Dogs: Impact on Electroencephalography, Behavior, Analgesia, and Antagonism With Atipamezole","volume":"11","author":"Ko Jeff C.","year":"2024","journal-title":"Veterinary Sciences"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2007.00344.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00236.x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.07.004"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2020.04.002"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12305"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2021.09.014"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2024.105254"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2024.105229"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12196"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.057"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.11.025"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1999.00659.x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2007.00365.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17722265"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-5823"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2020.11.005"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12220"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0659-7"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12623"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.34188\/bjaerv5n1-055"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106620"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-736x2014000500014"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb01941.x"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-736x2017001000023"},{"key":"e_1_2_10_27_2","volume-title":"Electrocardiography for the Small Animal Practitioner","author":"Tilley L. P.","year":"1999"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.78.2.158"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12989"},{"key":"e_1_2_10_30_2","volume-title":"R: A language and Environment for Statistical Computing","author":"R Core Team","year":"2024"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-84782004000400022"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2023.02.008"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2021.02.004"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.5152\/actavet.2024.23078"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2017:16:1"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.108.806828"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2012.01.027"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03566-4"}],"container-title":["Veterinary Medicine International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/vmi\/9947159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/vmi\/9947159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/vmi\/9947159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:15:07Z","timestamp":1772957707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/vmi\/9947159"}},"subtitle":[],"editor":[{"given":"Imtiaz","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/vmi\/9947159"],"URL":"https:\/\/doi.org\/10.1155\/vmi\/9947159","archive":["Portico"],"relation":{},"ISSN":["2090-8113","2042-0048"],"issn-type":[{"value":"2090-8113","type":"print"},{"value":"2042-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9947159"}}