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The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case\u2010control study, we investigated the effect of the C677T polymorphism in <jats:italic>MTHFR<\/jats:italic>, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of <jats:italic>MTHFR<\/jats:italic> C677T genotypes or of the T\u2010allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with <jats:italic>MTHFR<\/jats:italic> genotypes or with the T\u2010allele, in contrast with previous studies. Regarding the risk of the T\u2010allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T <jats:italic>MTHFR<\/jats:italic> polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.<\/jats:p>","DOI":"10.1155\/2008\/178679","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:37:23Z","timestamp":1371123443000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The C677T Polymorphism in <i>MTHFR<\/i> Is Not Associated with Migraine in Portugal"],"prefix":"10.1155","volume":"25","author":[{"given":"Anabela","family":"Ferro","sequence":"first","affiliation":[]},{"given":"Maria-Jos\u00e9","family":"Castro","sequence":"additional","affiliation":[]},{"given":"Carolina","family":"Lemos","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Alda","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Pereira-Monteiro","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Sequeiros","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Maciel","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,5,21]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2008\/178679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/178679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:14:06Z","timestamp":1723058046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/178679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/178679"],"URL":"https:\/\/doi.org\/10.1155\/2008\/178679","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2008-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}