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The present work presents a comprehensive study of the cytotoxicity and biocompatibility of NCD films grown by hot\u2010filament chemical vapour deposition (HFCVD) technique, aiming such future applications. Cytotoxicity was evaluated in vitro by seeding human gingival fibroblasts on the NCD surface for 14 days, while specific biocompatibility was assessed on samples seeded with human bone marrow\u2010derived osteoblasts during 21 days. The NCD coatings proved to be noncytotoxic in the preliminary human gingival fibroblast cell cultures, as denoted by a notable sequence of cell attachment, spreading, and proliferation events. In the specific biocompatibility assay envisaging bone tissue applications, NCD coatings induced human osteoblast proliferation and the stimulation of differentiation markers, compared to standard polystyrene tissue culture plates.<\/jats:p>","DOI":"10.1155\/2008\/894352","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T08:40:35Z","timestamp":1217234435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Nanocrystalline Diamond as a Coating for Joint Implants: Cytotoxicity and Biocompatibility Assessment"],"prefix":"10.1155","volume":"2008","author":[{"given":"Margarida","family":"Amaral","sequence":"first","affiliation":[]},{"given":"Pedro S.","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Maria A.","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 D.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Rui F.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Maria H.","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,7,27]]},"reference":[{"key":"e_1_2_6_1_2","first-page":"107","article-title":"Carbon coatings for medical implants","volume":"20","author":"Grabarczyk J.","year":"2007","journal-title":"Journal of Achievements in Materials and Manufacturing Engineering"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2004.03.003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2006.12.045"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2007.12.070"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)89777-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)81418-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)98822-V"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2006.08.142"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tsf.2007.05.054"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2006.12.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/la060167r"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2004.11.016"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pssa.200561932"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1808885"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.036"},{"key":"e_1_2_6_16_2","first-page":"10","article-title":"Revisiting the definition of biocompatibility","volume":"14","author":"Williams D.","year":"2003","journal-title":"Medical Device Technology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00007-1"},{"key":"e_1_2_6_18_2","first-page":"296","article-title":"The effects of silicon nitride ceramic on rabbit skeletal cells and tissues","author":"Howlett C.","year":"1989","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00249-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-9635(02)00305-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2006.07.024"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vacuum.2007.04.008"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-0134-1"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00284-7"},{"key":"e_1_2_6_25_2","volume-title":"Molecular Biology of the Cell","author":"Alberts B.","year":"2002"},{"key":"e_1_2_6_26_2","first-page":"133","volume-title":"A Textbook of Histology","author":"Fawcett D. 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