{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:18:16Z","timestamp":1769163496542,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Progetti di Ricerca di Interesse Nazionale","award":["2006038548"],"award-info":[{"award-number":["2006038548"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biomaterials"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>The most promising approach in Tissue Engineering involves the seeding of porous, biocompatible\/biodegradable scaffolds, with donor cells to promote tissue regeneration. \nAdditive biomanufacturing processes are increasingly recognized as ideal techniques to produce 3D structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in\u2010growing tissues. This paper presents a novel extrusion\u2010based system to produce 3D scaffolds with controlled internal\/external geometry for TE applications.The BioExtruder is a low\u2010cost system that uses a proper fabrication code based on the ISO programming language enabling the fabrication of multimaterial scaffolds. Poly(<jats:italic>\u03b5<\/jats:italic>\u2010caprolactone) was the material chosen to produce porous scaffolds, made by layers of directionally aligned microfilaments. Chemical, morphological, and in vitro biological evaluation performed on the polymeric constructs revealed a high potential of the BioExtruder to produce 3D scaffolds with regular and reproducible macropore architecture, without inducing relevant chemical and biocompatibility alterations of the material.<\/jats:p>","DOI":"10.1155\/2009\/239643","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T14:03:34Z","timestamp":1252418614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications"],"prefix":"10.1155","volume":"2009","author":[{"given":"Marco","family":"Domingos","sequence":"first","affiliation":[]},{"given":"Dinuccio","family":"Dinucci","sequence":"additional","affiliation":[]},{"given":"Stefania","family":"Cometa","sequence":"additional","affiliation":[]},{"given":"Michele","family":"Alderighi","sequence":"additional","affiliation":[]},{"given":"Paulo Jorge","family":"B\u00e1rtolo","sequence":"additional","affiliation":[]},{"given":"Federica","family":"Chiellini","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,9,8]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-68831-2_8"},{"key":"e_1_2_6_2_2","article-title":"Scaffolds designed and fabricated with elastic biomaterials applying CAD-CAM technique","volume":"14","author":"Hoque M. 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Design and development of tissue engineering scaffolds using rapid prototyping technology Ph.D. thesis 2007 National University of Singapore Singapore."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.08.018"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200700214"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/17452750701799303"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200105)55:2<203::AID-JBM1007>3.0.CO;2-7"},{"key":"e_1_2_6_14_2","unstructured":"AlmeidaH. A. MotaC. MateusA. B\u00e1rtoloP. J. FerreiraN. andDomingosM. Portuguese Patent no. 104247 2008."},{"key":"e_1_2_6_15_2","volume-title":"Virtual and rapid manufacturing","author":"Mateus A. 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