{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:47:11Z","timestamp":1769082431592,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The Chinese extract<jats:italic>Rhizoma coptidis<\/jats:italic>is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood.<jats:italic>Methods<\/jats:italic>. We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either<jats:italic>Rhizoma coptidis<\/jats:italic>extract or berberine. Activation of AP-1 and NF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B was analyzed in nuclear extracts, secretion of MCP-1\/CCL2 was measured in supernatants.<jats:italic>Results<\/jats:italic>. Incubation with<jats:italic>Rhizoma coptidis<\/jats:italic>and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP)-1 production in RAW cells. Activation of the transcription factors AP-1 and NF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B was inhibited by<jats:italic>Rhizoma coptidis<\/jats:italic>in a dose- and time-dependent fashion.<jats:italic>Conclusions. Rhizoma coptidis<\/jats:italic>extract inhibits LPS-induced MCP-1\/CCL2 production<jats:italic>in vitro<\/jats:italic>via an AP-1 and NF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine.<\/jats:p>","DOI":"10.1155\/2010\/194896","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T10:35:16Z","timestamp":1277116516000},"page":"1-8","source":"Crossref","is-referenced-by-count":54,"title":["<i>Rhizoma coptidis<\/i>Inhibits LPS-Induced MCP-1\/CCL2 Production in Murine Macrophages via an AP-1 and NF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B-Dependent Pathway"],"prefix":"10.1155","volume":"2010","author":[{"given":"Andrew","family":"Remppis","sequence":"first","affiliation":[{"name":"Medizinische Klinik III, Universit\u00e4t Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany"}]},{"given":"Florian","family":"Bea","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III, Universit\u00e4t Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany"}]},{"given":"Henry Johannes","family":"Greten","sequence":"additional","affiliation":[{"name":"Deutsche Gesellschaft f\u00fcr Traditionelle Chinesische Medizin (DGTCM), 69126 Heidelberg, Germany"},{"name":"Institute of Biomedical Sciences Abel Salazar, Porto University, 4099-002 Porto, Portugal"}]},{"given":"Annette","family":"Buttler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III, Universit\u00e4t Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany"}]},{"given":"Hongjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III, Universit\u00e4t Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany"}]},{"given":"Qianxing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III, Universit\u00e4t Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany"}]},{"given":"Michael R.","family":"Preusch","sequence":"additional","affiliation":[{"name":"Department of 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