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Several authors suggested specific mechanisms to explain this effect, but this matter was not clarified yet. We studied the actions of testosterone and cholesterol on endothelium-denuded rat aorta and their effects on the L-type<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msup><mml:mtext>Ca<\/mml:mtext><mml:mrow><mml:mn>2<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>current (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>I<\/mml:mtext><mml:mrow><mml:mtext>Ca,L<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>) and potassium current (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>I<\/mml:mtext><mml:mtext>K<\/mml:mtext><\/mml:msub><\/mml:math>). Testosterone (1\u2013100\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03bc<\/mml:mi><\/mml:math>M) totally relaxed, in a rapid and concentration-dependent way, the aortic rings contracted by KCl or by (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u2212<\/mml:mo><\/mml:math>)-Bay K8644 (BAY). Cholesterol also fully relaxed the contractions induced by KCl. None of the potassium channel antagonists tested (glibenclamide, tetraethylammonium and 4-aminopyridine) modified significantly the relaxant effect of testosterone. The antagonist of classic testosterone receptors, flutamide, did not modify the vasorelaxant effect of testosterone. Furthermore, testosterone and cholesterol inhibited either basal and BAY-stimulated<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>I<\/mml:mtext><mml:mrow><mml:mtext>Ca,L<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>in A7r5 cells and they have no effects on<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>I<\/mml:mtext><mml:mtext>K<\/mml:mtext><\/mml:msub><\/mml:math>. In summary, our results demonstrate that cholesterol and testosterone relax rat aorta by inhibiting LTCC. This effect of testosterone is not mediated by the classic hormone receptor or by potassium channel activation. These results suggest that the vasodilator mechanism of cholesterol and testosterone is the same.<\/jats:p>","DOI":"10.1155\/2010\/534184","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T15:31:04Z","timestamp":1269963064000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition"],"prefix":"10.1155","volume":"2010","author":[{"given":"E.","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"CICS\u2014Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"E.","family":"Cairr\u00e3o","sequence":"additional","affiliation":[{"name":"CICS\u2014Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Centro Hospitalar da Cova da Beira E.P.E., Quinta do Alvito, 6200-251 Covilh\u00e3, Portugal"}]},{"given":"M.","family":"Morgado","sequence":"additional","affiliation":[{"name":"CICS\u2014Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"C.","family":"Morais","sequence":"additional","affiliation":[{"name":"CICS\u2014Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"I.","family":"Verde","sequence":"additional","affiliation":[{"name":"CICS\u2014Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. 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