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Diabetic and obese ZDF (<jats:italic>fa\/fa<\/jats:italic>) rats and their controls (ZDF +\/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10\u2009mg\/kg\/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>, TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b1<\/mml:mi><\/mml:math>, CRP<jats:italic>hs<\/jats:italic>, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRP<jats:italic>hs<\/jats:italic>and IL-1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>. Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention. In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities.<\/jats:p>","DOI":"10.1155\/2010\/592760","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T14:35:43Z","timestamp":1277130943000},"page":"1-11","source":"Crossref","is-referenced-by-count":135,"title":["Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)"],"prefix":"10.1155","volume":"2010","author":[{"given":"Liliana","family":"Ferreira","sequence":"first","affiliation":[{"name":"Institute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 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