{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:10:22Z","timestamp":1762639822512,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/48168\/2008"],"award-info":[{"award-number":["SFRH\/BD\/48168\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Automated Methods and Management in Chemistry"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>A new flow procedure based on multicommutation with chemiluminometric detection was developed to quantify gentamicin sulphate in pharmaceutical formulations. This approach is based on gentamicin's ability to inhibit the chemiluminometric reaction between luminol and hypochlorite in alkaline medium, causing a decrease in the analytical signal. The inhibition of the analytical signal is proportional to the concentration of gentamicin sulphate, within a linear range of 1 to 4\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03bc<\/mml:mi><\/mml:math>g\u2009mL<jats:sup>-1<\/jats:sup>with a coefficient variation &lt;3%. A sample throughput of 55 samples h<jats:sup>-1<\/jats:sup>was obtained. The developed method is sensitive, simple, with low reagent consumption, reproducible, and inexpensive, and when applied to the analysis of pharmaceutical formulations (eye drops and injections) it gave results with RSD between 1.10 and 4.40%.<\/jats:p>","DOI":"10.1155\/2010\/913207","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T20:14:49Z","timestamp":1287000889000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["Development of a Multicommutated Flow System with Chemiluminometric Detection for Quantification of Gentamicin in Pharmaceuticals"],"prefix":"10.1155","volume":"2010","author":[{"given":"L\u00facia H. M. L. M.","family":"Santos","sequence":"first","affiliation":[{"name":"REQUIMTE, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"A. 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