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Diabetic and obese ZDF (fa\/fa) rats and their controls ZDF (+\/+) were treated for 6 weeks with vehicle (control) or sitagliptin (10\u2009mg\/kg\/bw). Blood\/serum glucose, HbA1c, insulin, Total-c, TGs, urea, and creatinine were assessed, as well as kidney glomerular and tubulointerstitial lesions (interstitial fibrosis\/tubular atrophy), using a semiquantitative rating from 0 (absent\/normal) to 3 (severe and extensive damage). Vascular lesions were scored from 0\u20132. Sitagliptin in the diabetic rats promoted an amelioration of glycemia, HbA1c, Total-c, and TGs, accompanied by a partial prevention of insulinopenia. Furthermore, together with urea increment prevention, renal lesions were ameliorated in the diabetic rats, including glomerular, tubulointerstitial, and vascular lesions, accompanied by reduced lipid peroxidation. In conclusion, chronic low-dose sitagliptin treatment was able to ameliorate diabetic nephropathy, which might represent a key step forward in the management of T2DM and this serious complication.<\/jats:p>","DOI":"10.1155\/2011\/162092","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T05:26:46Z","timestamp":1322803606000},"page":"1-12","source":"Crossref","is-referenced-by-count":114,"title":["Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)"],"prefix":"10.1155","volume":"2011","author":[{"given":"Cristina","family":"Mega","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, Institute for Biomedical Research on Light and Image (IBILI), Medicine Faculty, Coimbra University, 3000-548 Coimbra, Portugal"},{"name":"Agrarian School of Viseu, Polytechnic Institute of Viseu, 3500-606 Viseu, Portugal"},{"name":"Educational, 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