{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:21:02Z","timestamp":1777983662061,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["05\/57274-9"],"award-info":[{"award-number":["05\/57274-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.<\/jats:p>","DOI":"10.1155\/2011\/178475","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T07:43:35Z","timestamp":1371109415000},"page":"275-281","source":"Crossref","is-referenced-by-count":18,"title":["Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia"],"prefix":"10.1155","volume":"30","author":[{"given":"Lara","family":"Termini","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research \u2013 Hospital Alem\u00e3o Oswaldo Cruz, S\u00e3o Paulo (SP), Brazil"},{"name":"HPV Institute \u2013 INCT-HPV, Santa Casa de Miseric\u00f3rdia, S\u00e3o Paulo (SP), Brazil"}]},{"given":"Adhemar Longatto","family":"Filho","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, Braga, Portugal"},{"name":"Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of S\u00e3o Paulo, School of Medicine, S\u00e3o Paulo(SP), Brazil"}]},{"given":"Paulo Cesar","family":"Maciag","sequence":"additional","affiliation":[{"name":"HPV Institute \u2013 INCT-HPV, Santa Casa de Miseric\u00f3rdia, S\u00e3o Paulo (SP), Brazil"}]},{"given":"Daniela","family":"Etlinger","sequence":"additional","affiliation":[{"name":"Pathology Division, Adolfo Lutz Institute, S\u00e3o Paulo (SP), Brazil"}]},{"given":"Ven\u00e2ncio Avancini Ferreira","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of S\u00e3o Paulo, School of Medicine, S\u00e3o Paulo(SP), Brazil"}]},{"given":"Suely","family":"Nonogaki","sequence":"additional","affiliation":[{"name":"Pathology Division, Adolfo Lutz Institute, S\u00e3o Paulo (SP), Brazil"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Hospital do A. C. Camargo, S\u00e3o Paulo (SP), Brazil"},{"name":"Department of General Pathology, Faculty of Dentistry of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Luisa Lina","family":"Villa","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research \u2013 Hospital Alem\u00e3o Oswaldo Cruz, S\u00e3o Paulo (SP), Brazil"},{"name":"HPV Institute \u2013 INCT-HPV, Santa Casa de Miseric\u00f3rdia, S\u00e3o Paulo (SP), Brazil"}]}],"member":"311","container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2011\/178475.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2011\/178475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T18:31:02Z","timestamp":1519151462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2011\/178475\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"alternative-id":["178475"],"URL":"https:\/\/doi.org\/10.1155\/2011\/178475","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}