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Animals were sacrificed after 12 weeks of a swimming training program and after a single bout of acute extenuating exercise. Glycaemic, insulinemic, and lipidic profile (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum CRP<jats:italic>hs<\/jats:italic>, TNF-\u03b1, adiponectin) and oxidative (lipidic peroxidation and uric acid) status. When compared to obese diabetic sedentary rats, the animals submitted to acute exercise presented significantly lower values of glycaemia and insulinaemia, with inflammatory profile and oxidative stress significantly aggravated. The trained animals showed amelioration of glycaemic and lipidic dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative markers. In conclusion, the results presented herein suggessted that exercise pathogenesis-oriented interventions should not exacerbate underlying inflammatory stress associated with T2DM.<\/jats:p>","DOI":"10.1155\/2011\/253061","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T13:39:19Z","timestamp":1321450759000},"page":"1-8","source":"Crossref","is-referenced-by-count":35,"title":["Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2011","author":[{"given":"Edite","family":"Teixeira de Lemos","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, Institute for Biomedical Research on Light and Image (IBILI), Medicine Faculty, Coimbra University, 3000-548 Coimbra, Portugal"},{"name":"Educational, Technologies and Health Study Center, Polytechnic Institute of Viseu, 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