{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:29:03Z","timestamp":1773271743772,"version":"3.50.1"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["SFRH\/BPD\/37880\/2007"],"award-info":[{"award-number":["SFRH\/BPD\/37880\/2007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2012,9,25]]},"abstract":"<jats:p>A series of (<jats:italic>Z<\/jats:italic>)-2-benzylidenebenzofuran-3-(2H)-ones (aurones) bearing a variety of substituents on rings A and B were synthesized and evaluated for their antiparasitic activity against the intracellular amastigote form of <jats:italic>Leishmania infantum<\/jats:italic> and their cytotoxicity against human THP1-differentiated macrophages. In general, aurones bearing no substituents on ring A (compounds <jats:bold>4a\u20134f<\/jats:bold>) exhibit higher toxicity than aurones with 4,6-dimethoxy substitution (compounds <jats:bold>4g\u20134l<\/jats:bold>). Among the latter, two aurones possessing a 2\u2032-methoxy or a 2\u2032-methyl group (compounds <jats:bold>4i<\/jats:bold> and <jats:bold>4j<\/jats:bold>) exhibit potent antileishmanial activity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>IC<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>1.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.1<\/mml:mn><\/mml:mrow><\/mml:math>\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>M and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>IC<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>1.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.2<\/mml:mn><\/mml:mrow><\/mml:math>\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>M, resp.), comparable to the activity of the reference drug Amphotericin B, whereas they present significantly lower cytotoxicity than Amphotericin B as deduced by the higher selectivity index.<\/jats:p>","DOI":"10.1155\/2012\/196921","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T07:40:52Z","timestamp":1348645252000},"page":"1-8","source":"Crossref","is-referenced-by-count":24,"title":["Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents"],"prefix":"10.1155","volume":"2012","author":[{"given":"Marina","family":"Roussaki","sequence":"first","affiliation":[{"name":"Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece"}]},{"given":"Sofia","family":"Costa 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