{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:19:45Z","timestamp":1761765585984,"version":"3.37.3"},"reference-count":104,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["SFRH\/BD\/43399\/2008"],"award-info":[{"award-number":["SFRH\/BD\/43399\/2008"]}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["SFRH\/BD\/43399\/2008"],"award-info":[{"award-number":["SFRH\/BD\/43399\/2008"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Gu\u00e9rin (the BCG vaccine). This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with high-grade tumours, T1 tumours, and<jats:italic>in situ<\/jats:italic>carcinomas. However, from 20% to 40% of the patients do not respond and frequently present tumour progression. Since BCG effectiveness is unpredictable, it is important to find consistent biomarkers that can aid either in the prediction of the outcome and\/or side effects development. Accordingly, we conducted a systematic critical review to identify the most preeminent predictive molecular markers associated with BCG response. To the best of our knowledge, this is the first review exclusively focusing on predictive biomarkers for BCG treatment outcome. Using a specific query, 1324 abstracts were gathered, then inclusion\/exclusion criteria were applied, and finally 87 manuscripts were included. Several molecules, including CD68 and genetic polymorphisms, have been identified as promising surrogate biomarkers. Combinatory analysis of the candidate predictive markers is a crucial step to create a predictive profile of treatment response.<\/jats:p>","DOI":"10.1155\/2012\/232609","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T09:35:35Z","timestamp":1344332135000},"page":"1-17","source":"Crossref","is-referenced-by-count":21,"title":["Predictive Biomarkers of Bacillus Calmette-Gu\u00e9rin Immunotherapy Response in Bladder Cancer: Where Are We Now?"],"prefix":"10.1155","volume":"2012","author":[{"given":"Lu\u00eds","family":"Lima","sequence":"first","affiliation":[{"name":"Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, 4200-072 Porto, Portugal"},{"name":"ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal"},{"name":"Nucleo de Investiga\u00e7\u00e3o em Farm\u00e1cia, Centro de Estudos em Sa\u00fade e Ambiente (CISA), School of Allied Health Sciences, Polytechnic Institute of Oporto, 4400-330 Vila Nova de Gaia, Portugal"}]},{"given":"M\u00e1rio","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Portuguese Institute of Oncology, 4200-072 Porto, Portugal"},{"name":"CINTESIS\/Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of S\u00e3o Paulo, 01246903 S\u00e3o Paulo, SP, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, and ICVS\/3B\u2019s-PT Government Associate Laboratory, 4710-057 Braga, Portugal"},{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, 1331 Barretos, 1478-400 S\u00e3o Paulo, SP, Brazil"}]},{"given":"L\u00facio","family":"Santos","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, 4200-072 Porto, Portugal"},{"name":"Health Sciences Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Department of Surgical Oncology, Portuguese Institute of Oncology, 4200-072 Porto, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.12.014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.02306.x"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/S0022-5347(05)64273-5","volume":"168","year":"2002","journal-title":"Journal of Urology"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/S0022-5347(05)67523-4","volume":"163","year":"2000","journal-title":"Journal of Urology"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0090-4295(99)00591-9","volume":"55","year":"2000","journal-title":"Urology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.10.006"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-5347(17)46972-2","volume":"134","year":"1985","journal-title":"Journal of Urology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000066840.42991.4a"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2217\/1750743X.1.2.281"},{"issue":"3 i","key":"11","first-page":"596","volume":"147","year":"1992","journal-title":"Journal of Urology"},{"issue":"1","key":"12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0022-5347(05)64043-8","volume":"169","year":"2003","journal-title":"Journal of Urology"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0022-5347(05)67707-5","volume":"163","year":"2000","journal-title":"Journal of Urology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00357-9"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1074\/mcp.R300006-MCP200","volume":"2","year":"2003","journal-title":"Molecular & Cellular Proteomics"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.32"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"issue":"10","key":"18","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1200\/JCO.1996.14.10.2646","volume":"14","year":"1996","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1464-410X.1997.06911.x","volume":"79","year":"1997","journal-title":"British Journal of Urology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050040"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63731-5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61770-1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.018"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01551-5"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63839-4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.06.004"},{"issue":"1","key":"27","first-page":"52","volume":"27","year":"2005","journal-title":"Analytical and Quantitative Cytology and Histology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-005-0919-4"},{"issue":"9","key":"29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0210-4806(06)73553-7","volume":"30","year":"2006","journal-title":"Actas Urologicas Espanolas"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22503"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.09.062"},{"issue":"10","key":"32","first-page":"4201","volume":"29","year":"2009","journal-title":"Anticancer Research"},{"issue":"1","key":"33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0210-4806(01)72564-8","volume":"25","year":"2001","journal-title":"Actas Urologicas Espanolas"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.011"},{"issue":"6","key":"35","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1442-2042.1997.tb00307.x","volume":"4","year":"1997","journal-title":"International Journal of Urology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199907000-00017"},{"issue":"6","key":"37","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1159\/000020233","volume":"37","year":"2000","journal-title":"European Urology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1159\/000049768"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2008.08.003"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141894"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.01.040"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.11.090"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2010.11.017"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0969-6"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01909-X"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.07.118"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.06.006"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0595"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08342.x"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.02.053"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3323"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.085"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.04.020"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3816\/CGC.2009.n.016"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01696.x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0384-9"},{"issue":"5","key":"57","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/S0022-5347(05)64361-3","volume":"168","year":"2002","journal-title":"Journal of Urology"},{"issue":"4 b","key":"58","first-page":"3041","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"issue":"6","key":"59","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/S0022-5347(05)66983-2","volume":"164","year":"2000","journal-title":"Journal of Urology"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63835-7"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64210-1"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64111-9"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11352"},{"issue":"1","key":"64","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0022-5347(05)65469-9","volume":"167","year":"2002","journal-title":"Journal of Urology"},{"issue":"6","key":"65","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/S0022-5347(05)65522-X","volume":"166","year":"2001","journal-title":"Journal of Urology"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66424-3"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1159\/000087163"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000063685.29339.24"},{"issue":"4","key":"69","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000030530","volume":"64","year":"2000","journal-title":"Urologia Internationalis"},{"issue":"6","key":"70","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1200\/JCO.1996.14.6.1778","volume":"14","year":"1996","journal-title":"Journal of Clinical Oncology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00040-8"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000059681.67567.12"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.11.031"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00653-1"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1101"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0717-y"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9187-y"},{"issue":"5","key":"78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4161\/cbt.7.5.5763","volume":"7","year":"2008","journal-title":"Cancer Biology & Therapy"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0906-z"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1080\/13547500902818246"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2010.03.005"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.105"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.04.004"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.02.015"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08549.x"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.598"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.10.016"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0488-3"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2009.0982"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.3233\/DMA-2010-0724"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.01.001"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1153-6"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0035"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.09.026"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-1439(01)00153-3"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0557-9"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22588"},{"issue":"1","key":"98","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1442-2042.1997.tb00143.x","volume":"4","year":"1997","journal-title":"International Journal of Urology"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24770"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08375.x"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24258"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.03.001"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000149825.83180.a4"},{"issue":"4","key":"104","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0090-4295(01)00921-9","volume":"57","year":"2001","journal-title":"Urology"}],"container-title":["Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/232609.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/232609.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/232609.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T12:01:52Z","timestamp":1562068912000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/au\/2012\/232609\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":104,"alternative-id":["232609","232609"],"URL":"https:\/\/doi.org\/10.1155\/2012\/232609","relation":{},"ISSN":["1687-6369","1687-6377"],"issn-type":[{"type":"print","value":"1687-6369"},{"type":"electronic","value":"1687-6377"}],"subject":[],"published":{"date-parts":[[2012]]}}}