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The postmenopause lipid profile is clearly altered, which can present a risk factor for cardiovascular disease. Due to the role of mitochondria in fatty acid oxidation, alterations of the lipid profile in the menopausal women will also influence mitochondrial fatty acid oxidation fluxes in several organs. In this paper, we propose that alterations of mitochondrial bioenergetics in the heart, consequence from normal aging and\/or from the menopausal process, result in decreased fatty acid oxidation and accumulation of fatty acid intermediates in the cardiomyocyte cytosol, resulting in lipotoxicity and increasing the cardiovascular risk in the menopausal women.<\/jats:p>","DOI":"10.1155\/2012\/365798","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T16:00:28Z","timestamp":1328112028000},"page":"1-12","source":"Crossref","is-referenced-by-count":20,"title":["Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?"],"prefix":"10.1155","volume":"2012","author":[{"given":"Paulo J.","family":"Oliveira","sequence":"first","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal"}]},{"given":"Rui A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal"},{"name":"Department of Life Sciences, University of Coimbra, 3004-517 Coimbra, Portugal"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Public Medicine, Clinica Medica \u201cA. 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