{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:30:20Z","timestamp":1771655420669,"version":"3.50.1"},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PIC\/IC\/83214\/2007"],"award-info":[{"award-number":["PIC\/IC\/83214\/2007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Malaria Research and Treatment"],"published-print":{"date-parts":[[2012,4,11]]},"abstract":"<jats:p>Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle. This free Hz is ingested by circulating and resident phagocytes. The presence of Hz in tissues after clearance of infection has been previously reported. Still, little is known about the kinetics of Hz <jats:italic>in vivo<\/jats:italic>, during and after <jats:italic>Plasmodium<\/jats:italic> infection. It is particularly important to understand Hz kinetics after malaria infections as it has been reported that Hz is associated with impairment of immune functions, including possible consequences for coinfections. Indeed, if Hz remains biologically active for prolonged periods of time inside immunocompetent cells, the potential consequences of such accumulation and presence to the immune system should be clarified. Here, using several independent methods to assess the presence of Hz, we report the long-term <jats:italic>in vivo<\/jats:italic> kinetics of Hz in diverse organs in a murine model of malaria infection.<\/jats:p>","DOI":"10.1155\/2012\/373086","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T21:01:28Z","timestamp":1334178088000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["<i>In Vivo<\/i> Hemozoin Kinetics after Clearance of <i>Plasmodium berghei<\/i> Infection in Mice"],"prefix":"10.1155","volume":"2012","author":[{"given":"Rosangela","family":"Frita","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"given":"Daniel","family":"Carapau","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"given":"Maria 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