{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T22:30:51Z","timestamp":1774823451697,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Paullinia cupana<\/jats:italic>is used in weight-loss programs as a constituent of medicinal\/dietary supplements. This study aimed to assess a potential herb-drug interaction among a standardized (certified)<jats:italic>Paullinia cupana<\/jats:italic>extract and amiodarone (narrow therapeutic index drug) in rats. In a first pharmacokinetic study rats were simultaneously coadministered with a single dose of<jats:italic>Paullinia cupana<\/jats:italic>(821\u2009mg\/kg, p.o.) and amiodarone (50\u2009mg\/kg, p.o.), and in a second study rats were pretreated during 14 days with<jats:italic>Paullinia cupana<\/jats:italic>(821\u2009mg\/kg\/day, p.o.) receiving amiodarone (50\u2009mg\/kg, p.o.) on the 15th day. Rats of the control groups received the corresponding volume of vehicle. Blood samples were collected at several time points after amiodarone dosing, and several tissues were harvested at the end of the experiments (24\u2009h after dose). Plasma and tissue concentrations of amiodarone and its major metabolite (mono-<jats:italic>N<\/jats:italic>-desethylamiodarone) were measured and analysed. A significant reduction in the peak plasma concentration (73.2%) and in the extent of systemic exposure (57.8%) to amiodarone was found in rats simultaneously treated with<jats:italic>Paullinia cupana<\/jats:italic>and amiodarone; a decrease in tissue concentrations was also observed. This paper reports for the first time an herb-drug interaction between<jats:italic>Paullinia cupana<\/jats:italic>extract and amiodarone, which determined a great decrease on amiodarone bioavailability in rats.<\/jats:p>","DOI":"10.1155\/2012\/428560","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T23:54:47Z","timestamp":1354751687000},"page":"1-10","source":"Crossref","is-referenced-by-count":13,"title":["Herb-Drug Interaction of<i>Paullinia cupana<\/i>(Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats"],"prefix":"10.1155","volume":"2012","author":[{"given":"M\u00e1rcio","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Centre for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-517 Coimbra, Portugal"},{"name":"Health Sciences Research Centre (CICS), University of Beira Interior (UBI), 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