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Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also been implicated in the regulation of CLS. Acidification of the culture media mainly due to acetic acid and other organic acids production negatively impacts CLS. Ethanol is another fermentative metabolite capable of inducing CLS reduction in aged cells by yet unknown mechanisms. Recently, ammonium was reported to induce cell death associated with shortening of CLS. This effect is correlated to the concentration of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>NH<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>4<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>+<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>added to the culture medium and is particularly evident in cells starved for auxotrophy-complementing amino acids. Studies on the nutrient-signaling pathways regulating yeast aging had a significant impact on aging-related research, providing key insights into mechanisms that modulate aging and establishing the yeast as a powerful system to extend knowledge on longevity regulation in multicellular organisms.<\/jats:p>","DOI":"10.1155\/2012\/680304","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T21:04:35Z","timestamp":1344546275000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity"],"prefix":"10.1155","volume":"2012","author":[{"given":"J\u00falia","family":"Santos","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B's-PT Government Associate Laboratory, Life and Health Sciences Research Institute (ICVS), School of 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