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Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies. We measured acute-phase proteins (CRP and \u03b11-antitrypsin), proinflammatory cytokines (IL-6 and TNF-\u03b1), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), and uric acid levels. We studied 42 healthy pregnant women, 46 PE women, and their neonates. The concentrations of IL-6, TNF-\u03b1, \u03b11-antitrypsin, CRP, sVCAM, uric acid, and TBARS were significantly higher, and sL-selectin was significantly lower in PE pregnant women as compared with normotensive pregnant women. In newborns uric acid, \u03b11-antitrypsin, and CRP values were significantly higher in PE; leukocyte count, sL-selectin, lactoferrin, and the ratio elastase\/\u03b11-antitrypsin were significantly lower. Our data suggest that PE pregnancy is associated with an enhanced maternal inflammatory condition, which is reflected in fetal circulation. This enhanced inflammatory state seems to be related to endothelial dysfunction and increased cytokine synthesis, rather than with neutrophil activation.<\/jats:p>","DOI":"10.1155\/2012\/684384","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T07:12:21Z","timestamp":1338275541000},"page":"1-10","source":"Crossref","is-referenced-by-count":75,"title":["Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood"],"prefix":"10.1155","volume":"2012","author":[{"given":"Cristina","family":"Catarino","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Bioqu\u00edmica, Faculdade de Farm\u00e1cia da Universidade do Porto (FFUP), 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Bioqu\u00edmica, Faculdade de Farm\u00e1cia da Universidade do Porto (FFUP), 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Belo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Bioqu\u00edmica, Faculdade de Farm\u00e1cia da Universidade do Porto (FFUP), 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS), Universidade da Beira Interior, 6201-506 Covilh\u00e3, Portugal"}]},{"given":"Susana","family":"Rocha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Bioqu\u00edmica, Faculdade de Farm\u00e1cia da Universidade do Porto (FFUP), 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal"}]},{"given":"Belmiro","family":"Patr\u00edcio","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia e Ginecologia, Hospital de S. 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