{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:28:58Z","timestamp":1774787338089,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Foxp3<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge. To induce lung allergic inflammation, mice were sensitized twice with ovalbumin\/aluminum hydroxide gel and challenged twice with intranasal ovalbumin. Tolerance was induced by oral administration of ovalbumin for 5 consecutive days prior to OVA sensitization and challenge. We detected regulatory T cells (Foxp3<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>T cells) in the airways of allergic and tolerant mice; however, the number of regulatory T cells was more than 40-fold higher in allergic mice than in tolerant mice. Lung regulatory T cells expressed an effector\/memory phenotype (CCR4<jats:sup>high<\/jats:sup>CD62L<jats:sup>low<\/jats:sup>CD44<jats:sup>high<\/jats:sup>CD54<jats:sup>high<\/jats:sup>CD69<jats:sup>+<\/jats:sup>) that distinguished them from naive regulatory T cells (CCR4<jats:sup>int<\/jats:sup>CD62L<jats:sup>high<\/jats:sup>CD44<jats:sup>int<\/jats:sup>CD54<jats:sup>int<\/jats:sup>CD69<jats:sup>\u2212<\/jats:sup>). These regulatory T cells efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.<\/jats:p>","DOI":"10.1155\/2012\/721817","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T08:42:28Z","timestamp":1321432948000},"page":"1-13","source":"Crossref","is-referenced-by-count":26,"title":["Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production"],"prefix":"10.1155","volume":"2012","author":[{"given":"Lucas","family":"Faustino","sequence":"first","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, 05508-000 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Daniel","family":"Mucida","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA"}]},{"given":"Alexandre Castro","family":"Keller","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, 04023-900 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, 2780-901 Oeiras, Portugal"}]},{"given":"Karina","family":"Bortoluci","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Campus Diadema e Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de S\u00e3o Paulo, 04044-010 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Luiz Roberto","family":"Sardinha","sequence":"additional","affiliation":[{"name":"Instituto Israelita de Ensino e Pesquisa Albert Einstein, 05652-900 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Maisa","family":"Carla Takenaka","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, 04023-900 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Alexandre Salgado","family":"Basso","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, 04023-900 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Ana Maria Caetano","family":"Faria","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil"}]},{"given":"Momtchilo","family":"Russo","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, 05508-000 S\u00e3o Paulo, SP, 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