{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:44:29Z","timestamp":1769942669944,"version":"3.49.0"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The aim of this work was to study the anti-<jats:italic>Candida<\/jats:italic>activity of lidocaine and nitroglycerin alone and in combination. Ten<jats:italic>Candida<\/jats:italic>strains were included, corresponding to 1 collection type strain (ATCC 10231) and 9 clinical isolates: 4<jats:italic>C. albicans<\/jats:italic>, 2<jats:italic>C. glabrata<\/jats:italic>, 1<jats:italic>C. tropicalis<\/jats:italic>, 1<jats:italic>C. krusei<\/jats:italic>, and 1<jats:italic>C. parapsilosis<\/jats:italic>. The CLSI reference M27-A3 micromethod was used to determine the anti-<jats:italic>Candida<\/jats:italic>activity of the drugs alone; minimal inhibitory and lethal concentrations were determined. The classic checkboard technique was used to determine the activity of combined drugs. Lidocaine fungicidal effect was dosedependent. Nitroglycerin exhibited a higher effect. The drugs combination resulted in a reduction of the inhibitory concentration, corresponding to an additive effect. In conclusion, both drugs exhibited an interesting anti-<jats:italic>Candida<\/jats:italic>activity. The combination of lidocaine with nitroglycerin was shown to have an additive effect against<jats:italic>Candida<\/jats:italic>spp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis.<\/jats:p>","DOI":"10.1155\/2012\/727248","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T17:01:45Z","timestamp":1337533305000},"page":"1-4","source":"Crossref","is-referenced-by-count":11,"title":["<i>In Vitro<\/i>Anti-<i>Candida<\/i>Activity of Lidocaine and Nitroglycerin: Alone and Combined"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ana","family":"Palmeira-de-Oliveira","sequence":"first","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilh\u00e3, Portugal"}]},{"given":"Ana Rita","family":"Ramos","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilh\u00e3, Portugal"}]},{"given":"Carlos","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilh\u00e3, Portugal"}]},{"given":"Rita","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilh\u00e3, Portugal"}]},{"given":"Paula","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilh\u00e3, Portugal"},{"name":"Clinical Pathology Laboratory, Hospital Center Cova da Beira, Covilh\u00e3, Portugal"}]},{"given":"Jos\u00e9","family":"Martinez-de-Oliveira","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center (CICS), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. 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