{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:47Z","timestamp":1762917407757,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Caryocar brasiliense<\/jats:italic>Camb. \u201cpequi\u201d is a native plant from the Cerrado region of Brazil that contains bioactive components reported to be antioxidant agents. Previous work has demonstrated that dietary supplementation with pequi decreased the arterial pressure of volunteer athletes. We found that the crude hydroalcoholic extract (CHE) of<jats:italic>C. brasiliense<\/jats:italic>leaves relaxed, in a concentration-dependent manner, rat aortic rings precontracted with phenylephrine, and that the butanolic fraction (BF) produced an effect similar to that of the CHE. Aortic relaxation induced by BF was abolished by endothelium removal, by incubation of the nitric oxide synthase inhibitor L-NAME, or the soluble guanylatecyclase inhibitor ODQ. However, incubation with atropine and pyrilamine had no effect on the BF-induced vasorelaxation. Moreover, this effect was not inhibited by indomethacin and tetraethylammonium. The concentration-response curve to calcium in denuded-endothelium rings was not modified after incubation with BF, and the vasorelaxation by BF in endothelium-intact rings precontracted with KCl was abolished after incubation with L-NAME. In addition, administration of BF in anesthetized rats resulted in a reversible hypotension. The results reveal that<jats:italic>C. brasiliense<\/jats:italic>possesses both in vivo and in vitro activities and that the vascular effect of BF involves stimulation of the nitric oxide\/cyclic GMP pathway.<\/jats:p>","DOI":"10.1155\/2012\/934142","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T17:01:12Z","timestamp":1345050072000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from<i>Caryocar brasiliense<\/i>Camb. Leaves in Rat Thoracic Aorta"],"prefix":"10.1155","volume":"2012","author":[{"given":"Lais Moraes de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Molecular and Biochemistry Pharmacology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Campus Samambaia, Sala 215, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Aline Gabriela","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Molecular and Biochemistry Pharmacology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Campus Samambaia, Sala 215, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Elaine Fernanda da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Autonomic and Cardiac Physiology, Federal University of Goi\u00e1s, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Let\u00edcia Bonancio","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Study Center in Biopharmacy, Federal University of Paran\u00e1, 80210-170 Curitiba, PR, Brazil"}]},{"given":"Carlos Henrique","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Physiology of Isolated Organs, Federal University of Goi\u00e1s, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Gustavo Rodrigues","family":"Pedrino","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Autonomic and Cardiac Physiology, Federal University of Goi\u00e1s, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Maria Helena Catelli de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Hypertension, University of S\u00e3o Paulo, 05508-900 S\u00e3o Paulo, SP, Brazil"}]},{"given":"Roberto","family":"Pontarolo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Study Center in Biopharmacy, Federal University of Paran\u00e1, 80210-170 Curitiba, PR, Brazil"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Pharmacology of Natural Products, Federal University of Goi\u00e1s, 74001-970 Goi\u00e2nia, GO, Brazil"}]},{"given":"Francinete Ramos","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Study Center in Biopharmacy, Federal University of Paran\u00e1, 80210-170 Curitiba, PR, Brazil"}]},{"given":"Fernando Paranaiba","family":"Filgueira","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Laboratory of Molecular and Biochemistry Pharmacology, Institute of Biological Sciences, Federal University of Goi\u00e1s, Campus Samambaia, Sala 215, 74001-970 Goi\u00e2nia, 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