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This paper reviews the emerging field of acquired immune tolerance to non-self antigens, with an emphasis on the different subsets of induced regulatory T cells that appear to specialize in specific functional niches. Such regulatory mechanisms are important in preventing the onset of allergic diseases in healthy individuals. In addition, it may be possible to take advantage of these immune regulatory mechanisms for the induction of tolerance in cases where pathological immune responses are generated to allergens occurring in nature, but also to other immunogens such as biological drugs developed for medical therapies.<\/jats:p>","DOI":"10.1155\/2012\/948901","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T04:09:41Z","timestamp":1349064581000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Regulatory T Cells and the Control of the Allergic Response"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ana","family":"Agua-Doce","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Cellular Immunology Unit, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Instituto Gulbenkian de Ci\u00eancia, Cellular Immunology Unit, 2781-901 Oeiras, 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