{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:59:58Z","timestamp":1773323998547,"version":"3.50.1"},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Centro de Investiga\u00e7\u00e3o das Tecnologias da Sa\u00fade","award":["06-2011-CITS\/CESPU"],"award-info":[{"award-number":["06-2011-CITS\/CESPU"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obesity"],"published-print":{"date-parts":[[2013,1,17]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Our aim was to study how different BMI scores may influence the levels of inflammation, oxidative stress, adipogenesis, glucose, and lipid metabolism, in lean, overweight, and obese Portuguese patients with type 2 diabetes mellitus (T2DM). <jats:italic>Methods<\/jats:italic>. We studied 28 lean, 38 overweight, and 17 obese patients with T2DM and 20 controls (gender and age matched). The circulating levels of oxLDL, CRP, and some adipokines\u2014adiponectin, leptin, and chemerin\u2014and the lipid profile were evaluated. <jats:italic>Results<\/jats:italic>. Obese patients presented significantly lower levels of adiponectin and higher leptin, oxLDL, and chemerin levels, as compared to the overweight, lean, and control groups. Overweight, compared to lean and control, subjects showed significantly lower adiponectin and higher leptin and chemerin levels; oxLDL values were significantly higher in overweight than in lean patients. Lean patients presented significantly higher chemerin values than the control. Obese patients presented significantly higher CRP values, as compared to lean patients and the control group. Obese and overweight patients presented significantly higher triglycerides values than lean patients. Except for CRP, all the observed significant changes between control and patients remained significant after statistical adjustment for the body mass index (BMI). <jats:italic>Conclusion<\/jats:italic>. The levels of leptin, adiponectin, oxLDL, CRP, and triglycerides in patients with T2DM seem to be more associated with obesity and less with diabetes. Chemerin levels were raised in lean, overweight, and obese patients, suggesting that, independently of BMI, an adipocyte dysfunction occurs. Moreover, chemerin may provide an important early biomarker of adipocyte dysfunction and a link between obesity and type 2 diabetes mellitus.<\/jats:p>","DOI":"10.1155\/2013\/142097","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T21:01:48Z","timestamp":1358456508000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Adipokines, Oxidized Low-Density Lipoprotein, and C-Reactive Protein Levels in Lean, Overweight, and Obese Portuguese Patients with Type 2 Diabetes"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maria Jo\u00e3o","family":"Neuparth","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Actividade F\u00edsica, Sa\u00fade e Lazer, Universidade do Porto, Rua Dr. Pl\u00e1cido Costa 91, 4200-450 Porto, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o das Tecnologias da Sa\u00fade (CITS), Instituto Polit\u00e9cnico da Sa\u00fade do Norte (IPSN), Cooperativa de Ensino Superior, Polit\u00e9cnico e Universit\u00e1rio (CESPU), Rua Jos\u00e9 Ant\u00f3nio Vidal 81, 4760-409 Vila Nova de Famalic\u00e3o, Portugal"}]},{"given":"Jorge Brand\u00e3o","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto Superior de Ci\u00eancias da Sa\u00fade Norte (ISCS-N), CESPU, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo 228, 4050-313 Porto, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal"}]},{"given":"Susana","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o das Tecnologias da Sa\u00fade (CITS), Instituto Polit\u00e9cnico da Sa\u00fade do Norte (IPSN), Cooperativa de Ensino Superior, Polit\u00e9cnico e Universit\u00e1rio (CESPU), Rua Jos\u00e9 Ant\u00f3nio Vidal 81, 4760-409 Vila Nova de Famalic\u00e3o, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-010-0335-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1157\/13110464"},{"issue":"1","key":"3","first-page":"31","volume":"3","year":"2011","journal-title":"Clinical 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