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Traditional Chinese Medicine (TCM) offers empirical herbal formulas for the treatment of oral ulceration which are used in adaptation to chemotherapy-induced mucositis. While standard concepts for TCM treatment do not exist and acceptance by conventional oncologists is still low, we conducted a review to examine the evidence of Chinese herbal treatment in oral mucositis. Eighteen relevant studies on 4 single herbs, 2 combinations of 2 herbs, and 11 multiherbal prescriptions involving 3 or more compounds were included. Corresponding molecular mechanisms were investigated. The knowledge about detailed herbal mechanisms, especially in multi-herbal prescriptions is still limited. The quality of clinical trials needs further improvement. Meta-analysis on the existent database is not possible but molecular findings on Chinese medicinal herbs indicate that further research is still promising for the treatment of chemotherapy-induced oral mucositis.<\/jats:p>","DOI":"10.1155\/2013\/284959","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T21:03:24Z","timestamp":1382994204000},"page":"1-16","source":"Crossref","is-referenced-by-count":32,"title":["A Survey of Chinese Medicinal Herbal Treatment for Chemotherapy-Induced Oral Mucositis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Gesa","family":"Meyer-Hamme","sequence":"first","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, 20246 Hamburg, Germany"}]},{"given":"Kathrin","family":"Beckmann","sequence":"additional","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, 20246 Hamburg, Germany"}]},{"given":"Janine","family":"Radtke","sequence":"additional","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, 20246 Hamburg, Germany"}]},{"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany"}]},{"given":"Henry Johannes","family":"Greten","sequence":"additional","affiliation":[{"name":"ICBAS, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal"}]},{"given":"Matthias","family":"Rostock","sequence":"additional","affiliation":[{"name":"Institute of Complementary Medicine, University Hospital Zurich, 8006 Zurich, Switzerland"},{"name":"Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, 20246 Hamburg, Germany"}]},{"given":"Sven","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, 20246 Hamburg, Germany"},{"name":"ICBAS, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal"}]}],"member":"98","reference":[{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000283797","volume":"19","year":"2007","journal-title":"Schweizerische Zeitschrift f\u00fcr Ganzheitsmedizin"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.126018"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10318"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32833a9fab"},{"issue":"4","key":"6","first-page":"e314","volume":"27","year":"2010","journal-title":"International Journal of Biological Markers"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"e322","DOI":"10.5301\/JBM.2012.9936","volume":"27","year":"2012","journal-title":"International Journal of Biological Markers"},{"issue":"22","key":"8","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.12968\/bjon.2008.17.22.31870","volume":"17","year":"2008","journal-title":"British Journal of Nursing"},{"issue":"6","key":"13","first-page":"263","volume":"4","year":"2000","journal-title":"Clinical Journal of Oncology Nursing"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22484"},{"key":"11","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/00001622-199801000-00005","volume":"10","year":"1998","journal-title":"Current Opinion in Oncology"},{"issue":"29","key":"12","first-page":"31","year":"2001","journal-title":"Journal of the National Cancer Institute. 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