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The UVB-induced one-electron oxidation of Trp produces<jats:sup>\u2022<\/jats:sup>Trp and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>\u2022<\/mml:mo><\/mml:mrow><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>radicals which trigger lipid peroxidation. Immunoblots from buffered solutions or suction blister fluid reveal that propagation of photooxidative damage to other residues such as Tyr or disulfide bonds produces intra- and intermolecular bonds in apolipoproteins A-I, A-II, and B100. Partial repair of phenoxyl tyrosyl radicals (TyrO<jats:sup>\u2022<\/jats:sup>) by<jats:italic>\u03b1<\/jats:italic>-tocopherol is observed with LDL and HDL on millisecond or second time scales, whereas limited repair of<jats:italic>\u03b1<\/jats:italic>-tocopherol by carotenoids occurs in only HDL. More effective repair of Tyr and<jats:italic>\u03b1<\/jats:italic>-tocopherol is observed with the flavonoid, quercetin, bound to serum albumin, but quercetin is less potent than new synthetic polyphenols in inhibiting LDL lipid peroxidation or restoring<jats:italic>\u03b1<\/jats:italic>-tocopherol. The systemic consequences of HDL and LDL oxidation and the activation and\/or inhibition of signalling pathways by oxidized LDL and their ability to enhance transcription factor DNA binding activity are also reviewed.<\/jats:p>","DOI":"10.1155\/2013\/285825","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T21:15:25Z","timestamp":1366751725000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Lipoproteins as Mediators of the Oxidative Stress Induced by UV Light in Human Skin: A Review of Biochemical and Biophysical Studies on Mechanisms of Apolipoprotein Alteration, Lipid Peroxidation, and Associated Skin Cell Responses"],"prefix":"10.1155","volume":"2013","author":[{"given":"Paulo","family":"Filipe","sequence":"first","affiliation":[{"name":"Faculdade de Medicina de Lisboa, Hospital de Santa Maria, Cl\u00ednica Dermatologica Universitaria, Avenida Professor Egas Moniz, 1699 Lisboa Codex, Portugal"}]},{"given":"Patrice","family":"Morli\u00e8re","sequence":"additional","affiliation":[{"name":"INSERM, U1088, UFR de Pharmacie, 3 rue des Louvels, 80036 Amiens, France"},{"name":"CHU Amiens, P\u00f4le Biologie, Pharmacie et Sant\u00e9 des Populations, Centre de Biologie Humaine, Laboratoire de Biochimie, Avenue Ren\u00e9 Laennec, Salou\u00ebl, 80054 Amiens, France"},{"name":"UFR de M\u00e9decine et de Pharmacie, Universit\u00e9 de Picardie Jules Verne, 3 rue des Louvels, 80036 Amiens, France"}]},{"given":"Jo\u00e3o N.","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Lisboa, Hospital de Santa Maria, Cl\u00ednica Dermatologica Universitaria, Avenida Professor Egas Moniz, 1699 Lisboa Codex, Portugal"}]},{"given":"Jean-Claude","family":"Mazi\u00e8re","sequence":"additional","affiliation":[{"name":"INSERM, U1088, UFR de Pharmacie, 3 rue des Louvels, 80036 Amiens, France"},{"name":"CHU Amiens, P\u00f4le Biologie, Pharmacie et Sant\u00e9 des 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