{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:08:04Z","timestamp":1760828884786},"reference-count":41,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fundac\u00e3o para a Ci\u00eancia e Tecnologia","award":["PTDC\/DES\/67569\/2006","FCOMP-01-0124-FEDEB-09608","SFRH\/BD\/65290\/2009"],"award-info":[{"award-number":["PTDC\/DES\/67569\/2006","FCOMP-01-0124-FEDEB-09608","SFRH\/BD\/65290\/2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>. Family studies are well suited to investigate the genetic architecture underlying the metabolic syndrome (MetS). The purposes of this paper were (i) to estimate heritabilities for each of the MetS indicators, and (ii) to test the significance of familial intratrait and cross-trait correlations in MetS markers.<jats:italic>Methods and Results<\/jats:italic>. This study included 1,363 individuals from 515 Portuguese families in which five MetS components, including waist circumference (WC), blood pressure (BP), HDL-cholesterol, triglycerides (TG), and glucose (GLU), were measured. Intratrait and cross-trait familial correlations of these five components were estimated using Generalized Estimating Equations. Each MetS component was significantly heritable (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi>h<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>ranged from 0.12 to 0.60) and exhibited strong familial resemblance with correlations between biological relatives of similar magnitude to those observed between spouses. With respect to cross-trait correlations, familial resemblance was very weak except for the HDL-TG pair.<jats:italic>Conclusions<\/jats:italic>. The present findings confirm the idea of familial aggregation in MetS traits. Spousal correlations were, in general, of the same magnitude as the biological relatives' correlations suggesting that most of the phenotypic variance in MetS traits could be explained by shared environment.<\/jats:p>","DOI":"10.1155\/2013\/314823","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T21:04:35Z","timestamp":1379797475000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Familial Aggregation of Metabolic Syndrome Indicators in Portuguese Families"],"prefix":"10.1155","volume":"2013","author":[{"given":"D. M.","family":"Santos","sequence":"first","affiliation":[{"name":"CIFI2D, Faculty of Sports, University of Porto, Rua Dr. Pl\u00e1cido Costa 91, 4200-450 Porto, Portugal"}]},{"given":"P. T.","family":"Katzmarzyk","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA"}]},{"given":"D.-A.","family":"Tr\u00e9gouet","sequence":"additional","affiliation":[{"name":"INSERM, UMR S937, Institute for Cardiometabolism and Nutrition (ICAN), Pierre and Marie Curie University (UPMC, Paris6), 75654 Paris Cedex 13, France"}]},{"given":"T. N.","family":"Gomes","sequence":"additional","affiliation":[{"name":"CIFI2D, Faculty of Sports, University of Porto, Rua Dr. Pl\u00e1cido Costa 91, 4200-450 Porto, Portugal"}]},{"given":"F. K.","family":"Santos","sequence":"additional","affiliation":[{"name":"CIFI2D, Faculty of Sports, University of Porto, Rua Dr. Pl\u00e1cido Costa 91, 4200-450 Porto, Portugal"}]},{"given":"J. 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