{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:19:07Z","timestamp":1762521547686},"reference-count":32,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Hereditary diffuse gastric cancer is associated with the E-cadherin germline mutations, but genetic determinants have not been identified for familial intestinal gastric carcinoma. The guidelines for hereditary diffuse gastric cancer are clearly established; however, there are no defined recommendations for the management of familial intestinal gastric carcinoma.<jats:italic>Methods<\/jats:italic>. In this study we describe Pope John XXIII's pedigree that harboured gastric cancer as well as six other family members. Family history was analysed according to the International Gastric Cancer Linkage Consortium criteria, and gastric tumours were classified in accord with the last Japanese guidelines.<jats:italic>Results<\/jats:italic>. Seven out of 109 members in this pedigree harboured gastric cancer, affecting two consecutive generations. John XXIII's clinical tumour (cTN) was classified as cT4bN3a (IV stage). In two other cases, gastric carcinomas were classified as intestinal histotype and staged as pT1bN0 and pT2N2, respectively.<jats:italic>Conclusions<\/jats:italic>. Pope John XXIII's family presents a strong aggregation for gastric cancer affecting almost seven members; it spreads through two consecutive generations. In absence of defined genetic causes and considering the increased risk of gastric cancer\u2019s development in these families, as well as the high mortality rates and advanced stages, we propose an intensive surveillance protocol for asymptomatic members.<\/jats:p>","DOI":"10.1155\/2013\/385132","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T21:01:10Z","timestamp":1356555670000},"page":"1-8","source":"Crossref","is-referenced-by-count":35,"title":["History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family"],"prefix":"10.1155","volume":"2013","author":[{"given":"Giovanni","family":"Corso","sequence":"first","affiliation":[{"name":"Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology and Translational Research Laboratory, University of Siena, Viale Bracci, 53100 Siena, Italy"}]},{"given":"Fabrizio","family":"Roncalli","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale, Bergamo Province, Via alla Guardina 24039, Sotto il Monte Giovanni XXIII, Italy"}]},{"given":"Daniele","family":"Marrelli","sequence":"additional","affiliation":[{"name":"Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology and Translational Research Laboratory, University of Siena, Viale Bracci, 53100 Siena, Italy"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Medical Faculty of the University of Porto, st. John Hospital Center and Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), rua dr. Roberto Frias 4200-465 Porto, Portugal"}]},{"given":"Franco","family":"Roviello","sequence":"additional","affiliation":[{"name":"Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology and Translational Research Laboratory, University of Siena, Viale Bracci, 53100 Siena, Italy"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000113015"},{"issue":"12","key":"2","first-page":"873","volume":"36","year":"1999","journal-title":"Journal of Medical Genetics"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.074237"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-010-9410-1"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0002-9610(38)90653-1","volume":"40","year":"1938","journal-title":"The American Journal of Surgery"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/1097-0142(195809\/10)11:5<945::AID-CNCR2820110512>3.0.CO;2-7","volume":"11","year":"1958","journal-title":"Cancer"},{"key":"7","first-page":"287","volume":"63","year":"1964","journal-title":"The New Zealand Medical Journal"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/32918"},{"issue":"9","key":"9","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/sj.onc.1202033","volume":"17","year":"1998","journal-title":"Oncogene"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2008.01066.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.10.011"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-012-9521-y"},{"issue":"14","key":"14","first-page":"5415","volume":"61","year":"2001","journal-title":"Cancer Research"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27501"},{"issue":"20","key":"16","first-page":"5953","volume":"118","year":"2012","journal-title":"Cancer"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.049171"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.06.006"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921215)70:12<2935::AID-CNCR2820701234>3.0.CO;2-3"},{"issue":"1","key":"20","first-page":"15","volume":"3","year":"1994","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1294"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1349-7006.2003.tb01480.x","volume":"94","year":"2003","journal-title":"Cancer Science"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.04.005"},{"issue":"2","key":"24","first-page":"135","volume":"39","year":"2006","journal-title":"Journal of Preventive Medicine and Public Health"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01423.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23688"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605380"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200306000-00003"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-005-0350-7"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1177-8"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.02.004"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-19"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385132.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T04:51:50Z","timestamp":1498020710000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/385132\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":32,"alternative-id":["385132","385132"],"URL":"https:\/\/doi.org\/10.1155\/2013\/385132","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}