{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:21:14Z","timestamp":1760646074798,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100007044","name":"Sociedade Portuguesa de Nefrologia","doi-asserted-by":"publisher","award":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"],"award-info":[{"award-number":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"]}],"id":[{"id":"10.13039\/501100007044","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PIC","award":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"],"award-info":[{"award-number":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"]}]},{"name":"SFRH","award":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"],"award-info":[{"award-number":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"]}]},{"name":"SFRH","award":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"],"award-info":[{"award-number":["IC\/83029\/2007","BPD\/21782\/2005","BD\/39066\/2007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The edema formation in nephrotic syndrome (NS) is associated with a blunted response to atrial natriuretic peptide (ANP). The natriuretic effects of ANP have been related to renal dopamine D1-receptors (D1R). We examined the interaction between ANP and renal D1R in rats with puromycin aminonucleoside-induced NS (PAN-NS). Urinary sodium, cyclic guanosine monophosphate (cGMP) excretion, and D1R protein expression and localization in renal tubules were evaluated in PAN-NS and control rats before and during volume expansion (VE). The effects of zaprinast (phosphodiesterase type 5 inhibitor), alone or in combination with Sch-23390 (D1R antagonist), were examined in both groups. The increased natriuresis and urinary cGMP excretion evoked by acute VE were blunted in PAN-NS despite increased levels of circulating ANP. This was accompanied in PAN-NS by a marked decrease of D1R expression in the renal tubules. Infusion of zaprinast in PAN-NS resulted in increased urinary excretion of cGMP and sodium to similar levels of control rats and increased expression of D1R in the plasma membrane of renal tubular cells. Combined administration of Sch-23390 and zaprinast prevented natriuresis and increased cGMP excretion induced by zaprinast alone. We conclude that D1R may play a major role in the ANP resistance observed in PAN-NS.<\/jats:p>","DOI":"10.1155\/2013\/397391","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T21:02:01Z","timestamp":1373922121000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome"],"prefix":"10.1155","volume":"2013","author":[{"given":"C\u00e1tia","family":"Fernandes-Cerqueira","sequence":"first","affiliation":[{"name":"Nephrology Research & Development Unit, Faculty of Medicine, University of Porto & Hospital S. Jo\u00e3o EPE, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-8075","authenticated-orcid":true,"given":"Benedita","family":"Sampaio-Maia","sequence":"additional","affiliation":[{"name":"Nephrology Research & Development Unit, Faculty of Medicine, University of Porto & Hospital S. Jo\u00e3o EPE, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Faculty of Dental Medicine, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal"}]},{"given":"Janete","family":"Quelhas-Santos","sequence":"additional","affiliation":[{"name":"Nephrology Research & Development Unit, Faculty of Medicine, University of Porto & Hospital S. Jo\u00e3o EPE, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"M\u00f3nica","family":"Moreira-Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of General Physiology, Unit for Multidisciplinary Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal"}]},{"given":"Liliana","family":"Sim\u00f5es-Silva","sequence":"additional","affiliation":[{"name":"Nephrology Research & Development Unit, Faculty of Medicine, University of Porto & Hospital S. Jo\u00e3o EPE, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Ana M.","family":"Blazquez-Medela","sequence":"additional","affiliation":[{"name":"Renal y Cardiovascular Physiopathology Research Unit, Instituto Reina Sofia de Investigaci\u00f3n Nefrol\u00f3gica, Department of Physiology and Pharmacology, University of Salamanca, Edificio Departamental S-20 Campus Miguel de Unamuno, 37007 Salamanca, Spain"}]},{"given":"C.","family":"Martinez-Salgado","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n (IECSCYL), Research Unit, University Hospital of Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain"}]},{"given":"Jose M.","family":"Lopez-Novoa","sequence":"additional","affiliation":[{"name":"Renal y Cardiovascular Physiopathology Research Unit, Instituto Reina Sofia de Investigaci\u00f3n Nefrol\u00f3gica, Department of Physiology and Pharmacology, University of Salamanca, Edificio Departamental S-20 Campus Miguel de Unamuno, 37007 Salamanca, Spain"}]},{"given":"Manuel","family":"Pestana","sequence":"additional","affiliation":[{"name":"Nephrology Research & Development Unit, Faculty of Medicine, University of Porto & Hospital S. 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