{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:49:33Z","timestamp":1758991773363},"reference-count":32,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Ophthalmology"],"published-print":{"date-parts":[[2013,7,30]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. <jats:italic>Materials and Methods<\/jats:italic>. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and \u22653 years of followup. \nBaseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). <jats:italic>Results<\/jats:italic>. The follow-up period was <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>60.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>31.3<\/mml:mn><\/mml:math> months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95%\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><\/mml:math>\n                 0.088\u20130.162). The absolute number of drusen in the central 1000 and 3000\u2009<jats:italic>\u03bc<\/jats:italic>m (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and the absolute number of drusen \u2265125 \u00b5m in the central 3000 and 6000 \u00b5m (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) proved to be significant risk factors for CNV. <jats:italic>Conclusion<\/jats:italic>. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00801541\">NCT00801541<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2013\/464218","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T21:01:59Z","timestamp":1375218119000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jo\u00e3o Pedro","family":"Marques","sequence":"first","affiliation":[{"name":"Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), 3000-075 Coimbra, Portugal"},{"name":"Association for Innovation and Biomedical Research on Light and Image (AIBILI), 3000-548 Coimbra, Portugal"}]},{"given":"Miguel","family":"Costa","sequence":"additional","affiliation":[{"name":"Association for Innovation 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