{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:24:22Z","timestamp":1754195062835,"version":"3.40.4"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/65483\/2009"],"award-info":[{"award-number":["SFRH\/BD\/65483\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>169<\/mml:mn><\/mml:math>) and control subjects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>73<\/mml:mn><\/mml:math>) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-<jats:italic>\u03b1<\/jats:italic>, adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients\u2019 subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients\u2019 subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.<\/jats:p>","DOI":"10.1155\/2013\/612038","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T03:08:52Z","timestamp":1382670532000},"page":"1-12","source":"Crossref","is-referenced-by-count":9,"title":["Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin"],"prefix":"10.1155","volume":"2013","author":[{"given":"Filipa","family":"Mascarenhas-Melo","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (P\u00f3lo III), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Jos\u00e9","family":"Sereno","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (P\u00f3lo III), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Edite","family":"Teixeira-Lemos","sequence":"additional","affiliation":[{"name":"ESAV and Educational Technologies and Health Study Center, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal"}]},{"given":"Daniela","family":"Marado","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, General Hospital, University and Hospital Centre of Coimbra, 3041-801 S\u00e3o Martinho do Bispo, Portugal"}]},{"given":"Filipe","family":"Palavra","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (P\u00f3lo III), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Neurology Department, General Hospital, University and Hospital Centre of Coimbra, 3041-801 S\u00e3o Martinho do Bispo, Portugal"}]},{"given":"Rui","family":"Pinto","sequence":"additional","affiliation":[{"name":"Pharmacology and Pharmacotoxicology Unit, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"Research Centre for Health Sciences, Beira Interior University, 6201-001 Covilh\u00e3, Portugal"}]},{"given":"Frederico","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (P\u00f3lo III), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Fl\u00e1vio","family":"Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (P\u00f3lo III), University of Coimbra, 3000-548 Coimbra, 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