{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:17:52Z","timestamp":1758633472165,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"],"award-info":[{"award-number":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian National Research Council","award":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"],"award-info":[{"award-number":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"]}]},{"name":"PAPES","award":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"],"award-info":[{"award-number":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"]}]},{"name":"PDTIS","award":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"],"award-info":[{"award-number":["U19 AI56541","CNPq 150911\/2003-3","403652\/2008-1","RVR09-FIOCRUZ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher\u2019s association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.047<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.025, 95% CI = 0.97\u20134.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.048<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 0.501, one-sided 95% CI = 0\u20130.99) and HLA-DR*13 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 0.511, one-sided 95% CI = 0\u20130.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B*44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B*07 supertype alleles and DR*13 might be involved in cross-dengue serotype immunity.<\/jats:p>","DOI":"10.1155\/2013\/648475","type":"journal-article","created":{"date-parts":[[2013,6,2]],"date-time":"2013-06-02T21:01:15Z","timestamp":1370206875000},"page":"1-11","source":"Crossref","is-referenced-by-count":14,"title":["HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population"],"prefix":"10.1155","volume":"2013","author":[{"given":"Liciana","family":"Xavier Eurico de Alencar","sequence":"first","affiliation":[{"name":"Virology and Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center, Fiocruz, Avenida Moraes Rego s\/n, Campus da UFPE, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"}]},{"given":"Ulisses","family":"de Mendon\u00e7a Braga-Neto","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Texas A&M University, 3128 TAMU, Station College Station, TX 77843-3128, USA"}]},{"given":"Eduardo","family":"Jos\u00e9 Moura do Nascimento","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Center for Vaccine Research, University of Pittsburgh, 3501 Fifth Avenue, Biomedical Science Tower 3, Room 9022, Pittsburgh, PA 15261, USA"}]},{"given":"Marli","family":"Ten\u00f3rio Cordeiro","sequence":"additional","affiliation":[{"name":"Virology and Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center, Fiocruz, Avenida Moraes Rego s\/n, Campus da UFPE, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"},{"name":"Central Laboratory of Public Health, Secretaria de Sa\u00fade do Estado de Pernambuco, Pra\u00e7a Oswaldo Cruz s\/n, Boa Vista, 50050-210 Recife, PE, Brazil"}]},{"given":"Ana","family":"Maria 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