{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:29:16Z","timestamp":1758126556534,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Unit for Multidisciplinary Investigation in Biomedicine, Porto, Portugal"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx). We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year. Urine samples were collected on post-KTx days 0, 1, 2, 4, and 7. Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used. At all-time points, mean uNGAL levels were significantly higher in patients developing DGF (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>18<\/mml:mn><\/mml:math>). Shortly after KTx (3\u20136\u2009h), uNGAL values were higher in DGF recipients (on average +242\u2009ng\/mL, considering mean dialysis time of 4.1 years) and rose further in following days, contrasting with prompt function recipients. Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95). Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine. Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.<\/jats:p>","DOI":"10.1155\/2013\/650123","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T03:09:43Z","timestamp":1383275383000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function"],"prefix":"10.1155","volume":"2013","author":[{"given":"Isabel","family":"Fonseca","sequence":"first","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Investigation in Biomedicine (UMIB), 4099-003 Porto, Portugal"}]},{"given":"Jos\u00e9 Carlos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemical Chemistry, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"}]},{"given":"Manuela","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Investigation in Biomedicine (UMIB), 4099-003 Porto, Portugal"}]},{"given":"Madalena","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Chemical Chemistry, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"}]},{"given":"Anabela","family":"Malho","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"}]},{"given":"La Salete","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Investigation in Biomedicine (UMIB), 4099-003 Porto, Portugal"}]},{"given":"Leon\u00eddio","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-906X","authenticated-orcid":true,"given":"Sofia","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, 4099-001 Porto, Portugal"}]},{"given":"Josefina","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, Centro 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